The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD

Abstract Dysregulations in monoaminergic systems have been implicated in attention deficit/hyperactivity disorder. The spontaneous hypertensive rats (SHR) are used as an animal model for ADHD. Juvenile SHR rats exhibited low dopamine transporter (DAT) density, low vesicular monoamine transporter 2 (...

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Veröffentlicht in:	European neuropsychopharmacology 2010-10, Vol.20 (10), p.714-720
Hauptverfasser:	Simchon, Y, Weizman, A, Rehavi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder (ADHD) Binding Sites Brain - drug effects Brain - metabolism Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter (DAT) Internal Medicine Male Methylphenidate (MPH) Methylphenidate - administration & dosage Methylphenidate - pharmacology Piperazines - metabolism Psychiatry Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Dopamine - metabolism Spontaneous hypertensive rats (SHR) Synaptosomes - drug effects Synaptosomes - metabolism Tetrabenazine - analogs & derivatives Tetrabenazine - metabolism Time Factors Vesicular Monoamine Transport Proteins - metabolism Vesicular monoamine transporter 2 (VMAT2) Wistar Kyoto rats (WKY)
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Zusammenfassung:	Abstract Dysregulations in monoaminergic systems have been implicated in attention deficit/hyperactivity disorder. The spontaneous hypertensive rats (SHR) are used as an animal model for ADHD. Juvenile SHR rats exhibited low dopamine transporter (DAT) density, low vesicular monoamine transporter 2 (VMAT2) density and lower unstimulated dopamine (DA) release in comparison to their corresponding WKY controls. Chronic methylphenidate treatment of the young SHR rats was associated with lower DAT density and lower unstimulated basal dopamine release but with enhanced potassium- and amphetamine-induced dopamine release. These neurochemical alterations might be relevant to the pathophysiology and to the beneficial effect of methylphenidate in ADHD.
ISSN:	0924-977X 1873-7862
DOI:	10.1016/j.euroneuro.2010.04.007