A pilot study of reduced toxicity conditioning with BU, fludarabine and alemtuzumab before the allogeneic hematopoietic SCT in children and adolescents

We report the results of a pilot study of a BU–fludarabine–alemtuzumab (BFA)-reduced toxicity conditioning (RTC) followed by allogeneic hematopoietic SCT (AlloHSCT) in 12 children and adolescents (

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Bibliographische Detailangaben
Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2011-06, Vol.46 (6), p.790-799
Hauptverfasser:	Styczynski, J, Tallamy, B, Waxman, I, van de Ven, C, Milone, M C, Shaw, L M, Harrison, L, Morris, E, Satwani, P, Bhatia, M, George, D, Bradley, M B, Garvin, J H, Schwartz, J, Baxter-Lowe, L A, Cairo, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/1729 692/699/67 692/700/565/545/576/1955 Adolescent Adolescents Alemtuzumab Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antibodies, Neoplasm Antimitotic agents Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan CD34 antigen Cell Biology Child Child, Preschool Children Chimerism Conditioning Cord blood Drugs Female Fludarabine Graft rejection Graft Survival Graft vs Host Disease - classification Graft-versus-host reaction Grafts Health aspects Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - mortality Hematopoietic stem cells Humans Internal Medicine Leukocytes (neutrophilic) Male Medical sciences Medicine Medicine & Public Health Monoclonal antibodies Mycophenolate mofetil Mycophenolic acid original-article Pilot Projects Prophylaxis Public Health Stem cell transplantation Stem Cells Survival Analysis Tacrolimus Teenagers Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Chimera Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplantation, Homologous Vidarabine - analogs & derivatives Young Adult
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Beschreibung
Zusammenfassung:	We report the results of a pilot study of a BU–fludarabine–alemtuzumab (BFA)-reduced toxicity conditioning (RTC) followed by allogeneic hematopoietic SCT (AlloHSCT) in 12 children and adolescents (
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2010.209