IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

Highlight ► IFN-β therapy induces IL-27, which inhibits pathogenic Th17 cells that mediate autoimmunity in MS and EAE.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-08, Vol.25 (6), p.1170-1181
Hauptverfasser:	Sweeney, Cheryl M, Lonergan, Roisin, Basdeo, Sharee A, Kinsella, Katie, Dungan, Lara S, Higgins, Sarah C, Kelly, Patrick J, Costelloe, Lisa, Tubridy, Niall, Mills, Kingston H.G, Fletcher, Jean M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Animals CD4+ T cell CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cells, Cultured - drug effects Cells, Cultured - immunology Cells, Cultured - metabolism Dendritic cell Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Experimental autoimmune encephalomyelitis Female Gene Expression Regulation - drug effects Humans IFN-β IL-27 Interferon beta-1a Interferon beta-1b Interferon-alpha - deficiency Interferon-alpha - genetics Interferon-beta - pharmacology Interferon-beta - therapeutic use Interleukins - antagonists & inhibitors Interleukins - biosynthesis Interleukins - genetics Interleukins - physiology Male Mice Mice, Inbred Strains Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - physiopathology Psychiatry Th17 Th17 Cells - drug effects Th17 Cells - immunology Toll-Like Receptors - drug effects Toll-Like Receptors - physiology Young Adult Zymosan - pharmacology
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Beschreibung
Zusammenfassung:	Highlight ► IFN-β therapy induces IL-27, which inhibits pathogenic Th17 cells that mediate autoimmunity in MS and EAE.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.03.007