Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis

Highlight ► Stimulation of cannabinoid CB1 receptors dampens the synaptic effects of TNFα, explaining the neuroprotective action of cannabinoids in neuroinflammatory disorders.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-08, Vol.25 (6), p.1242-1248
Hauptverfasser:	Rossi, Silvia, Furlan, Roberto, Chiara, Valentina De, Muzio, Luca, Musella, Alessandra, Motta, Caterina, Studer, Valeria, Cavasinni, Francesca, Bernardi, Giorgio, Martino, Gianvito, Cravatt, Benjamin F, Lutz, Beat, Maccarrone, Mauro, Centonze, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Allergy and Immunology Amidohydrolases - deficiency Anandamide Animals Arachidonic Acids - biosynthesis Arachidonic Acids - physiology Cannabinoid Receptor Modulators - physiology Corpus Striatum - physiopathology Dizocilpine Maleate - pharmacology Dronabinol - analogs & derivatives Dronabinol - pharmacology EAE Encephalomyelitis, Autoimmune, Experimental - physiopathology Endocannabinoids EPSC Etanercept Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitotoxicity FAAH Female Glutamic Acid - physiology Immunoglobulin G - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Nerve Degeneration Neurodegeneration Neurons - physiology Polyunsaturated Alkamides Psychiatry Receptor, Cannabinoid, CB1 - deficiency Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - physiology Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology
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Beschreibung
Zusammenfassung:	Highlight ► Stimulation of cannabinoid CB1 receptors dampens the synaptic effects of TNFα, explaining the neuroprotective action of cannabinoids in neuroinflammatory disorders.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.03.017