Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity

3,4‐Methylenedioxymethamphetamine (MDMA)‐induced neurotoxicity leads to the formation of quinone metabolities and hydroxyl radicals and then to the production of reactive oxygen species (ROS). We evaluated the effect of a single dose of MDMA (20 mg/kg, i.p.) on the enzymatic and nonenzymatic cellula...

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Veröffentlicht in:	Journal of neuroscience research 2010-03, Vol.88 (4), p.905-916
Hauptverfasser:	Riezzo, Irene, Cerretani, Daniela, Fiore, Carmela, Bello, Stefania, Centini, Fabio, D'Errico, Stefano, Fiaschi, Anna Ida, Giorgi, Giorgio, Neri, Margherita, Pomara, Cristoforo, Turillazzi, Emanuela, Fineschi, Vittorio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Biomarkers - metabolism Brain - drug effects Brain - metabolism Brain - pathology Chromatography, High Pressure Liquid - methods Disease Models, Animal Electrochemistry - methods Glial Fibrillary Acidic Protein - metabolism Glutathione - metabolism Hallucinogens - metabolism Hallucinogens - toxicity HSP70 HSP70 Heat-Shock Proteins - metabolism Male Malondialdehyde MDMA N-Methyl-3,4-methylenedioxyamphetamine - metabolism N-Methyl-3,4-methylenedioxyamphetamine - toxicity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Reactive Oxygen Species - metabolism Time Factors Vesicular Monoamine Transport Proteins - metabolism VMAT2
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Zusammenfassung:	3,4‐Methylenedioxymethamphetamine (MDMA)‐induced neurotoxicity leads to the formation of quinone metabolities and hydroxyl radicals and then to the production of reactive oxygen species (ROS). We evaluated the effect of a single dose of MDMA (20 mg/kg, i.p.) on the enzymatic and nonenzymatic cellular antioxidant defense system in different areas of rat brain in the early hours (
ISSN:	0360-4012 1097-4547 1097-4547
DOI:	10.1002/jnr.22245