Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat
Summary Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for eval...
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| Veröffentlicht in: | Tuberculosis (Edinburgh, Scotland) Scotland), 2011-07, Vol.91 (4), p.339-341 |
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| container_end_page | 341 |
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| container_issue | 4 |
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| container_title | Tuberculosis (Edinburgh, Scotland) |
| container_volume | 91 |
| creator | Heng, YiXiong Seah, Peck Gee Siew, Jie Yee Tay, Hui Chien Singhal, Amit Mathys, Vanessa Kiass, Mehdi Bifani, Pablo Dartois, Véronique Hervé, Maxime |
| description | Summary Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo. |
| doi_str_mv | 10.1016/j.tube.2011.05.003 |
| format | Article |
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Seah, Peck Gee ; Siew, Jie Yee ; Tay, Hui Chien ; Singhal, Amit ; Mathys, Vanessa ; Kiass, Mehdi ; Bifani, Pablo ; Dartois, Véronique ; Hervé, Maxime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-da651b17dabec300e8f7aaebabeb412f708dd157e0bda3d8205e27c71f4e8a6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Granuloma - microbiology</topic><topic>Histopathology</topic><topic>Hypoxia</topic><topic>Hypoxia - pathology</topic><topic>Immunohistochemistry</topic><topic>Infectious Disease</topic><topic>Lung - microbiology</topic><topic>Lung - pathology</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - pathogenicity</topic><topic>Nitroimidazoles - pharmacology</topic><topic>Pimonidazole</topic><topic>Pulmonary/Respiratory</topic><topic>Rat</topic><topic>Rats</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heng, YiXiong</creatorcontrib><creatorcontrib>Seah, Peck Gee</creatorcontrib><creatorcontrib>Siew, Jie Yee</creatorcontrib><creatorcontrib>Tay, Hui Chien</creatorcontrib><creatorcontrib>Singhal, Amit</creatorcontrib><creatorcontrib>Mathys, Vanessa</creatorcontrib><creatorcontrib>Kiass, Mehdi</creatorcontrib><creatorcontrib>Bifani, Pablo</creatorcontrib><creatorcontrib>Dartois, Véronique</creatorcontrib><creatorcontrib>Hervé, Maxime</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Tuberculosis (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heng, YiXiong</au><au>Seah, Peck Gee</au><au>Siew, Jie Yee</au><au>Tay, Hui Chien</au><au>Singhal, Amit</au><au>Mathys, Vanessa</au><au>Kiass, Mehdi</au><au>Bifani, Pablo</au><au>Dartois, Véronique</au><au>Hervé, Maxime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat</atitle><jtitle>Tuberculosis (Edinburgh, Scotland)</jtitle><addtitle>Tuberculosis (Edinb)</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>91</volume><issue>4</issue><spage>339</spage><epage>341</epage><pages>339-341</pages><issn>1472-9792</issn><eissn>1873-281X</eissn><abstract>Summary Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. 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| fulltext | fulltext |
| identifier | ISSN: 1472-9792 |
| ispartof | Tuberculosis (Edinburgh, Scotland), 2011-07, Vol.91 (4), p.339-341 |
| issn | 1472-9792 1873-281X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Disease Models, Animal Female Granuloma - microbiology Histopathology Hypoxia Hypoxia - pathology Immunohistochemistry Infectious Disease Lung - microbiology Lung - pathology Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Nitroimidazoles - pharmacology Pimonidazole Pulmonary/Respiratory Rat Rats Tuberculosis Tuberculosis, Pulmonary - pathology |
| title | Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat |
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