Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Summary Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for eval...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tuberculosis (Edinburgh, Scotland) Scotland), 2011-07, Vol.91 (4), p.339-341
Hauptverfasser: Heng, YiXiong, Seah, Peck Gee, Siew, Jie Yee, Tay, Hui Chien, Singhal, Amit, Mathys, Vanessa, Kiass, Mehdi, Bifani, Pablo, Dartois, Véronique, Hervé, Maxime
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Summary Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2011.05.003