Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones
6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity. 6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathog...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2011-01, Vol.21 (1), p.427-430 |
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| container_end_page | 430 |
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| container_issue | 1 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Ryu, Chung-Kyu Lee, Seung-Yon Kim, Na Young Hong, Jung An Yoon, Joo Hee Kim, Aram |
| description | 6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity.
6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents. |
| doi_str_mv | 10.1016/j.bmcl.2010.10.124 |
| format | Article |
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6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.</description><subject>6-Hydroxy-1H-carbazole-1,4(9H)-diones</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>antifungal properties</subject><subject>Antimicrobial compounds</subject><subject>Biological and medical sciences</subject><subject>Carbazoles - chemical synthesis</subject><subject>Carbazoles - chemistry</subject><subject>Carbazoles - pharmacology</subject><subject>chemistry</subject><subject>Fungi</subject><subject>Fungi - drug effects</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>antifungal properties</topic><topic>Antimicrobial compounds</topic><topic>Biological and medical sciences</topic><topic>Carbazoles - chemical synthesis</topic><topic>Carbazoles - chemistry</topic><topic>Carbazoles - pharmacology</topic><topic>chemistry</topic><topic>Fungi</topic><topic>Fungi - drug effects</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Structure-Activity Relationship</topic><topic>Substitution effects</topic><topic>virulent strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Chung-Kyu</creatorcontrib><creatorcontrib>Lee, Seung-Yon</creatorcontrib><creatorcontrib>Kim, Na Young</creatorcontrib><creatorcontrib>Hong, Jung An</creatorcontrib><creatorcontrib>Yoon, Joo Hee</creatorcontrib><creatorcontrib>Kim, Aram</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryu, Chung-Kyu</au><au>Lee, Seung-Yon</au><au>Kim, Na Young</au><au>Hong, Jung An</au><au>Yoon, Joo Hee</au><au>Kim, Aram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>21</volume><issue>1</issue><spage>427</spage><epage>430</epage><pages>427-430</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity.
6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>21075635</pmid><doi>10.1016/j.bmcl.2010.10.124</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.427-430 |
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| subjects | 6-Hydroxy-1H-carbazole-1,4(9H)-diones Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology antifungal properties Antimicrobial compounds Biological and medical sciences Carbazoles - chemical synthesis Carbazoles - chemistry Carbazoles - pharmacology chemistry Fungi Fungi - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship Substitution effects virulent strains |
| title | Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones |
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