Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones

6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity. 6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathog...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-01, Vol.21 (1), p.427-430
Hauptverfasser:	Ryu, Chung-Kyu, Lee, Seung-Yon, Kim, Na Young, Hong, Jung An, Yoon, Joo Hee, Kim, Aram
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxy-1H-carbazole-1,4(9H)-diones Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology antifungal properties Antimicrobial compounds Biological and medical sciences Carbazoles - chemical synthesis Carbazoles - chemistry Carbazoles - pharmacology chemistry Fungi Fungi - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship Substitution effects virulent strains
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Zusammenfassung:	6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity. 6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.10.124