The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production

The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production

The methoxychlor metabolite, HPTE, was shown to inhibit P450-cholesterol side-chain cleavage (P450scc) activity resulting in decreased progesterone production by cultured ovarian follicular cells in previous studies. It is not known whether HPTE has any effect on progesterone formation by the corpus...

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Veröffentlicht in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-07, Vol.32 (1), p.77-84
Hauptverfasser: Akgul, Yucel, Derk, Raymond C., Meighan, Terence, Rao, K. Murali Krishna, Murono, Eisuke P.
Format: Artikel
Sprache:eng
Schlagworte:
8-Bromo Cyclic Adenosine Monophosphate - pharmacology
Animals
Biological and medical sciences
Cholesterol side-chain cleavage
Cholesterol Side-Chain Cleavage Enzyme - metabolism
Chorionic Gonadotropin - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Estrogens - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression - drug effects
HPTE
Luteal cells
Luteal Cells - drug effects
Luteal Cells - metabolism
Medical sciences
Methoxychlor
Ovarian steroidogenesis
P450scc
Pesticides, fertilizers and other agrochemicals toxicology
Phenols - toxicity
Progesterone - antagonists & inhibitors
Progesterone - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
Teratology. Teratogens
Toxicology
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Zusammenfassung:The methoxychlor metabolite, HPTE, was shown to inhibit P450-cholesterol side-chain cleavage (P450scc) activity resulting in decreased progesterone production by cultured ovarian follicular cells in previous studies. It is not known whether HPTE has any effect on progesterone formation by the corpus luteum. Exposure to 100 nM HPTE reduced progesterone production by luteal cells with progressive declines to
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2011.05.013