An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum

Three new compounds, 3-hydroxyhericenone F ( 1), hericenone I ( 2), and hericenone J ( 3), were isolated from the mushroom Hericium erinaceum. The structures of 1– 3 were determined by the interpretation of spectral data. Compound 1 showed the protective activity against endoplasmic reticulum (ER) s...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-11, Vol.16 (21), p.9467-9470
Hauptverfasser:	Ueda, Keiko, Tsujimori, Megumi, Kodani, Shinya, Chiba, Akiko, Kubo, Masakazu, Masuno, Kazuhiko, Sekiya, Atsushi, Nagai, Kaoru, Kawagishi, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Animals Basidiocarps Biological and medical sciences Biological Products - chemistry Biological Products - pharmacology Cell death Cell Proliferation - drug effects Data processing Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress suppression General pharmacology Hericenone Hericium erinaceum Medical sciences Mice Molecular Structure Mushroom Neuroblastoma - metabolism Neuroblastoma - pathology Neurodegenerative disease Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - pharmacology
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Zusammenfassung:	Three new compounds, 3-hydroxyhericenone F ( 1), hericenone I ( 2), and hericenone J ( 3), were isolated from the mushroom Hericium erinaceum. The structures of 1– 3 were determined by the interpretation of spectral data. Compound 1 showed the protective activity against endoplasmic reticulum (ER) stress-dependent Neuro2a cell death, however, compounds 2 and 3 did not.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2008.09.044