Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation
Highlights ► HCV Core induces p16 promoter hypermethylation via up-regulation of DNMT1 and 3b. ► Core inhibits p16 expression to inactivate Rb and subsequently activate E2F1. ► Core stimulates growth of hepatocytes.
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| Veröffentlicht in: | Cancer letters 2011-11, Vol.310 (1), p.61-68 |
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| container_end_page | 68 |
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| container_issue | 1 |
| container_start_page | 61 |
| container_title | Cancer letters |
| container_volume | 310 |
| creator | Park, Sun-Hye Lim, Joo Song Lim, Su-Yeon Tiwari, Indira Jang, Kyung Lib |
| description | Highlights ► HCV Core induces p16 promoter hypermethylation via up-regulation of DNMT1 and 3b. ► Core inhibits p16 expression to inactivate Rb and subsequently activate E2F1. ► Core stimulates growth of hepatocytes. |
| doi_str_mv | 10.1016/j.canlet.2011.06.012 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-a78e8013f6fb13ad33cc5ab2b070cdd4f15463b1d8e6e8c1f78fcaa0b78f6cc83</citedby><cites>FETCH-LOGICAL-c567t-a78e8013f6fb13ad33cc5ab2b070cdd4f15463b1d8e6e8c1f78fcaa0b78f6cc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030438351100348X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21757290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Sun-Hye</creatorcontrib><creatorcontrib>Lim, Joo Song</creatorcontrib><creatorcontrib>Lim, Su-Yeon</creatorcontrib><creatorcontrib>Tiwari, Indira</creatorcontrib><creatorcontrib>Jang, Kyung Lib</creatorcontrib><title>Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights ► HCV Core induces p16 promoter hypermethylation via up-regulation of DNMT1 and 3b. ► Core inhibits p16 expression to inactivate Rb and subsequently activate E2F1. ► Core stimulates growth of hepatocytes.</description><subject>Amino Acid Sequence</subject><subject>Blotting, Western</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Cell division</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Core</subject><subject>Cyclin D1 - metabolism</subject><subject>Cyclin-Dependent Kinase Inhibitor p15 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p15 - metabolism</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA (Cytosine-5-)-Methyltransferase 1</subject><subject>DNA (Cytosine-5-)-Methyltransferases - metabolism</subject><subject>DNA Methylation</subject><subject>DNA Methyltransferase 3B</subject><subject>Down-Regulation</subject><subject>G1 Phase - genetics</subject><subject>Gene expression</subject><subject>gene expression regulation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hep G2 Cells</subject><subject>Hepatitis</subject><subject>Hepatitis C virus</subject><subject>Hepatoblastoma - genetics</subject><subject>Hepatoblastoma - metabolism</subject><subject>Hepatoblastoma - pathology</subject><subject>Hepatocellular carcinoma</subject><subject>hepatocytes</subject><subject>hepatoma</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Humans</subject><subject>Kinases</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>mechanism of action</subject><subject>Molecular Sequence Data</subject><subject>p16</subject><subject>Phosphorylation</subject><subject>Plasmids</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Proteins</subject><subject>RNA Interference</subject><subject>Rodents</subject><subject>S Phase - genetics</subject><subject>Signal transduction</subject><subject>Transfection</subject><subject>Transgenic animals</subject><subject>Tumors</subject><subject>Viral Core Proteins - genetics</subject><subject>Viral Core Proteins - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxSMEokvhGyCwxAEuWcZx_GcvSNVCKVIFh1KJm-U4k6232TjYTst--zraAlIPcHoH_-Zpnt8UxUsKSwpUvN8urRl6TMsKKF2CWAKtHhULqmRVypWCx8UCGNQlU4wfFc9i3AIAryV_WhxVVHJZrWBRXJ_haJJLLpI1uXFhyuoDkjH4hG4gMbnd1JuEkVjse7IJ_jZdkWZPWn87lAE386sbNmSkguCvMWCMzg_Zy5CPX0_IDtPVfkb88Lx40pk-4ot7PS4uTz99X5-V598-f1mfnJeWC5lKIxUqoKwTXUOZaRmzlpumakCCbdu6o7wWrKGtQoHK0k6qzhoDTVZhrWLHxduDbw7xc8KY9M7FeXszoJ-iVooBiBpWmXz3T5JyARQklTP65gG69VMYco5M0VpxtVrVmaoPlA0-xoCdHoPbmbDXFPRcm97qQ216rk2D0Lm2PPbq3nxqdtj-GfrdUwZeH4DOeG02wUV9eZEdeO6UVZLPoT8cCMw_e-Mw6GgdDhZbF9Am3Xr3vx0eGtjeDc6a_hr3GP-m1bHSoC_m45pvi9K8Qq1-sDtkwMkn</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Park, Sun-Hye</creator><creator>Lim, Joo Song</creator><creator>Lim, Su-Yeon</creator><creator>Tiwari, Indira</creator><creator>Jang, Kyung Lib</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation</title><author>Park, Sun-Hye ; Lim, Joo Song ; Lim, Su-Yeon ; Tiwari, Indira ; Jang, Kyung Lib</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-a78e8013f6fb13ad33cc5ab2b070cdd4f15463b1d8e6e8c1f78fcaa0b78f6cc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino Acid Sequence</topic><topic>Blotting, Western</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell Cycle - genetics</topic><topic>Cell division</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Core</topic><topic>Cyclin D1 - metabolism</topic><topic>Cyclin-Dependent Kinase Inhibitor p15 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p15 - metabolism</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA (Cytosine-5-)-Methyltransferase 1</topic><topic>DNA (Cytosine-5-)-Methyltransferases - metabolism</topic><topic>DNA Methylation</topic><topic>DNA Methyltransferase 3B</topic><topic>Down-Regulation</topic><topic>G1 Phase - genetics</topic><topic>Gene expression</topic><topic>gene expression regulation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hep G2 Cells</topic><topic>Hepatitis</topic><topic>Hepatitis C virus</topic><topic>Hepatoblastoma - genetics</topic><topic>Hepatoblastoma - 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| ispartof | Cancer letters, 2011-11, Vol.310 (1), p.61-68 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Blotting, Western Cell culture Cell cycle Cell Cycle - genetics Cell division Cell growth Cell Line Cell Proliferation Core Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p15 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA Methyltransferase 3B Down-Regulation G1 Phase - genetics Gene expression gene expression regulation Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatitis Hepatitis C virus Hepatoblastoma - genetics Hepatoblastoma - metabolism Hepatoblastoma - pathology Hepatocellular carcinoma hepatocytes hepatoma Host-Pathogen Interactions - genetics Humans Kinases Liver - cytology Liver - metabolism Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology mechanism of action Molecular Sequence Data p16 Phosphorylation Plasmids Promoter Regions, Genetic - genetics Proteins RNA Interference Rodents S Phase - genetics Signal transduction Transfection Transgenic animals Tumors Viral Core Proteins - genetics Viral Core Proteins - metabolism |
| title | Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation |
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