Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation

Highlights ► HCV Core induces p16 promoter hypermethylation via up-regulation of DNMT1 and 3b. ► Core inhibits p16 expression to inactivate Rb and subsequently activate E2F1. ► Core stimulates growth of hepatocytes.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2011-11, Vol.310 (1), p.61-68
Hauptverfasser:	Park, Sun-Hye, Lim, Joo Song, Lim, Su-Yeon, Tiwari, Indira, Jang, Kyung Lib
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Blotting, Western Cell culture Cell cycle Cell Cycle - genetics Cell division Cell growth Cell Line Cell Proliferation Core Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p15 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA Methyltransferase 3B Down-Regulation G1 Phase - genetics Gene expression gene expression regulation Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatitis Hepatitis C virus Hepatoblastoma - genetics Hepatoblastoma - metabolism Hepatoblastoma - pathology Hepatocellular carcinoma hepatocytes hepatoma Host-Pathogen Interactions - genetics Humans Kinases Liver - cytology Liver - metabolism Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology mechanism of action Molecular Sequence Data p16 Phosphorylation Plasmids Promoter Regions, Genetic - genetics Proteins RNA Interference Rodents S Phase - genetics Signal transduction Transfection Transgenic animals Tumors Viral Core Proteins - genetics Viral Core Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► HCV Core induces p16 promoter hypermethylation via up-regulation of DNMT1 and 3b. ► Core inhibits p16 expression to inactivate Rb and subsequently activate E2F1. ► Core stimulates growth of hepatocytes.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.06.012