DNA copy number profile discriminates between esophageal adenocarcinoma and squamous cell carcinoma and represents an independent prognostic parameter in esophageal adenocarcinoma

Highlights ► We report comparison of DNA copy number alterations in esophageal ADC and SCC samples. ► ADC are characterized by an elevated genomic instability; SCC present more specific clustered abnormalities. ► Total DNA copy number changes were found to be an independent prognostic factor for ADC...

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Veröffentlicht in:	Cancer letters 2011-11, Vol.310 (1), p.84-93
Hauptverfasser:	Rumiato, Enrica, Pasello, Giulia, Montagna, Marco, Scaini, Maria Chiara, De Salvo, Gian Luca, Parenti, Anna, Cagol, Matteo, Ruol, Alberto, Ancona, Ermanno, Amadori, Alberto, Saggioro, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	ADC adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adult Aged Aged, 80 and over biomarkers Cancer therapies carcinogenesis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Chromosome Aberrations Chromosomes Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Deoxyribonucleic acid Diagnosis, Differential DNA DNA copy number DNA, Neoplasm - genetics Esophageal adenocarcinoma Esophageal cancer esophageal neoplasms Esophageal Neoplasms - diagnosis Esophageal Neoplasms - genetics Esophageal squamous cell carcinoma Female Gene Amplification Gene Deletion Gene Dosage Genes Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Kinases Male Medical prognosis Middle Aged MLPA Nucleic Acid Amplification Techniques - methods Oligonucleotide Probes - genetics patients Prognosis Proteins SCC squamous cell carcinoma Tumors Vascular Endothelial Growth Factor A - genetics
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Zusammenfassung:	Highlights ► We report comparison of DNA copy number alterations in esophageal ADC and SCC samples. ► ADC are characterized by an elevated genomic instability; SCC present more specific clustered abnormalities. ► Total DNA copy number changes were found to be an independent prognostic factor for ADC but not for SCC patients.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.06.017