Targeted pH-dependent fluorescent activity-based cathepsin probes
Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2011-09, Vol.47 (33), p.9363-9365 |
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| container_end_page | 9365 |
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| container_issue | 33 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 47 |
| creator | Hoogendoorn, Sascha Habets, Kim L Passemard, Solène Kuiper, Johan van der Marel, Gijsbert A Florea, Bogdan I Overkleeft, Herman S |
| description | Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition. |
| doi_str_mv | 10.1039/c1cc12947c |
| format | Article |
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Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.</description><subject>Animals</subject><subject>Boron Compounds - chemistry</subject><subject>Cathepsins - metabolism</subject><subject>Cellular</subject><subject>Clusters</subject><subject>Compartments</subject><subject>Cysteine</subject><subject>Dendritic Cells - metabolism</subject><subject>Dyes</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Leucine - analogs & derivatives</subject><subject>Leucine - chemistry</subject><subject>Mannose</subject><subject>Mannose - chemistry</subject><subject>Mice</subject><subject>Microscopy, Fluorescence</subject><subject>Uptakes</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK1u_AHSnSJEc-eVmWUpaoWCmwruwjxuNJImMTMR-u9NqI-dd3PO4uPcwyHkHNIbSJm-deAcUM0zd0CmwCRPBFcvh6MXOskYFxNyEsJ7OhwIdUwmFDKpGdVTstiY7hUj-nm7Sjy2WHus47yo-qbD4EZvXCw_y7hLrAkD50x8wzaU9bztGovhlBwVpgp49q0z8nx_t1mukvXTw-NysU4cAx0TK03hWcGYN0pypr0tjEemlJJDW47CZpxqSyFFbriQLBWcy0xl1gspHLAZudznDm8_egwx35ZDwaoyNTZ9yJWiqVLAR_LqXxIoBSVBMDWg13vUdU0IHRZ525Vb0-1ySPNx3Pxv3AG--M7t7Rb9L_qzJvsChUt0HQ</recordid><startdate>20110907</startdate><enddate>20110907</enddate><creator>Hoogendoorn, Sascha</creator><creator>Habets, Kim L</creator><creator>Passemard, Solène</creator><creator>Kuiper, Johan</creator><creator>van der Marel, Gijsbert A</creator><creator>Florea, Bogdan I</creator><creator>Overkleeft, Herman S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20110907</creationdate><title>Targeted pH-dependent fluorescent activity-based cathepsin probes</title><author>Hoogendoorn, Sascha ; Habets, Kim L ; Passemard, Solène ; Kuiper, Johan ; van der Marel, Gijsbert A ; Florea, Bogdan I ; Overkleeft, Herman S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-b6afd3f33da86439dbfade388865484e5b7429b210e4a456305446787bd565c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Boron Compounds - chemistry</topic><topic>Cathepsins - metabolism</topic><topic>Cellular</topic><topic>Clusters</topic><topic>Compartments</topic><topic>Cysteine</topic><topic>Dendritic Cells - metabolism</topic><topic>Dyes</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Leucine - analogs & derivatives</topic><topic>Leucine - chemistry</topic><topic>Mannose</topic><topic>Mannose - chemistry</topic><topic>Mice</topic><topic>Microscopy, Fluorescence</topic><topic>Uptakes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoogendoorn, Sascha</creatorcontrib><creatorcontrib>Habets, Kim L</creatorcontrib><creatorcontrib>Passemard, Solène</creatorcontrib><creatorcontrib>Kuiper, Johan</creatorcontrib><creatorcontrib>van der Marel, Gijsbert A</creatorcontrib><creatorcontrib>Florea, Bogdan I</creatorcontrib><creatorcontrib>Overkleeft, Herman S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoogendoorn, Sascha</au><au>Habets, Kim L</au><au>Passemard, Solène</au><au>Kuiper, Johan</au><au>van der Marel, Gijsbert A</au><au>Florea, Bogdan I</au><au>Overkleeft, Herman S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted pH-dependent fluorescent activity-based cathepsin probes</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2011-09-07</date><risdate>2011</risdate><volume>47</volume><issue>33</issue><spage>9363</spage><epage>9365</epage><pages>9363-9365</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.</abstract><cop>England</cop><pmid>21769329</pmid><doi>10.1039/c1cc12947c</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2011-09, Vol.47 (33), p.9363-9365 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_882088141 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Boron Compounds - chemistry Cathepsins - metabolism Cellular Clusters Compartments Cysteine Dendritic Cells - metabolism Dyes Fluorescence Fluorescent Dyes - chemistry Hydrogen-Ion Concentration Leucine - analogs & derivatives Leucine - chemistry Mannose Mannose - chemistry Mice Microscopy, Fluorescence Uptakes |
| title | Targeted pH-dependent fluorescent activity-based cathepsin probes |
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