Role of chicken Pit-1 isoforms in activating growth hormone gene

Highlights ► Chicken Pit-1α and Pit-1γ localized in the nuclei in COS-7 cells. ► Chicken Pit-1α and Pit-1γ induced transactivation of chicken GH gene, but Pit-1α was a more potent isoform in the activation of chicken GH gene. ► Forskolin promoted induction of chGH gene with chicken Pit-1α and Pit-1γ...

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Veröffentlicht in:	General and comparative endocrinology 2011-09, Vol.173 (2), p.248-252
Hauptverfasser:	Murase, Daisuke, Taniuchi, Shusuke, Takeuchi, Sakae, Adachi, Hiromi, Kansaku, Norio, Okazaki, Katsuichiro, Ohkubo, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Cercopithecus aethiops Chicken Chickens COS Cells Endocrinology & Metabolism forskolin green fluorescent protein Green Fluorescent Proteins Growth hormone Growth Hormone - genetics luciferase Pit-1 Promoter Promoter Regions, Genetic - genetics Protein Isoforms - genetics Protein Isoforms - metabolism reporter genes somatotropin Transcription Factor Pit-1 - genetics Transcription Factor Pit-1 - metabolism transcriptional activation
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Beschreibung
Zusammenfassung:	Highlights ► Chicken Pit-1α and Pit-1γ localized in the nuclei in COS-7 cells. ► Chicken Pit-1α and Pit-1γ induced transactivation of chicken GH gene, but Pit-1α was a more potent isoform in the activation of chicken GH gene. ► Forskolin promoted induction of chGH gene with chicken Pit-1α and Pit-1γ at similar extent.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2011.06.007