N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide

Native chemical ligation: N‐sulfanylethylanilide (SEAlide) peptides act as thioester peptides in the presence of N‐terminal cysteinyl peptides and an appropriate choice of salts. With the use of the SEAlide peptide, a kinetically controlled native chemical ligation proceeding in an unprecedented highly selective manner was achieved. Additionally, a one‐pot, four‐component coupling under kinetic conditions was achieved.