Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones

Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N‐limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-08, Vol.12 (12), p.1836-1839
Hauptverfasser:	Scherlach, Kirstin, Sarkar, Anindita, Schroeckh, Volker, Dahse, Hans-Martin, Roth, Martin, Brakhage, Axel A., Horn, Uwe, Hertweck, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Anthraquinones - metabolism Anthraquinones - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Aspergillus nidulans - genetics Aspergillus nidulans - metabolism Bioreactors biosynthesis Biotechnology - methods Fermentation Gene Expression Profiling Gene Expression Regulation, Fungal genome mining Humans K562 Cells Magnetic Resonance Spectroscopy Metabolic Networks and Pathways - physiology Nitrogen - deficiency Polyketide Synthases - genetics Polyketide Synthases - metabolism polyphenols Resorcinols - metabolism sanghaspirodin Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization spiro compounds Transcriptional Activation
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Zusammenfassung:	Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N‐limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid‐derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201100132