Protein Chemical Synthesis by Ligation of Peptide Hydrazides
pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long‐sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemic...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2011-08, Vol.50 (33), p.7645-7649 |
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| container_issue | 33 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 50 |
| creator | Fang, Ge-Min Li, Yi-Ming Shen, Fei Huang, Yi-Chao Li, Jia-Bin Lin, Yun Cui, Hong-Kui Liu, Lei |
| description | pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long‐sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemical ligation. |
| doi_str_mv | 10.1002/anie.201100996 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2011-08, Vol.50 (33), p.7645-7649 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Hydrazines - chemical synthesis Hydrazines - chemistry Molecular Structure native chemical ligation Oligopeptides - chemical synthesis Oligopeptides - chemistry peptide hydrazides protein chemical synthesis protein design proteins |
| title | Protein Chemical Synthesis by Ligation of Peptide Hydrazides |
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