Protein Chemical Synthesis by Ligation of Peptide Hydrazides

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long‐sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2011-08, Vol.50 (33), p.7645-7649
Hauptverfasser: Fang, Ge-Min, Li, Yi-Ming, Shen, Fei, Huang, Yi-Chao, Li, Jia-Bin, Lin, Yun, Cui, Hong-Kui, Liu, Lei
Format: Artikel
Sprache:eng
Schlagworte:
Hydrazines - chemical synthesis
Hydrazines - chemistry
Molecular Structure
native chemical ligation
Oligopeptides - chemical synthesis
Oligopeptides - chemistry
peptide hydrazides
protein chemical synthesis
protein design
proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long‐sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemical ligation.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201100996