Postnatal growth and cardiometabolic profile in young adults born large for gestational age

Summary Context The association between large for gestational age (LGA) phenotype, postnatal growth and cardiometabolic risk (CMR) in adult life remains unclear. The role of IGF1 genotype on LGA‐related outcomes in adult life is unknown. Aim To assess the postnatal growth, IGF‐I levels, CMR and the influence of the 737.738 IGF1 in adults born LGA. Subjects Case–control study (n = 515) nested in a population‐based prospective cohort (n = 2063); 117 LGA and 398 gender‐matched controls appropriate for gestational age (AGA) subjects. Methods Anthropometry was evaluated at birth, at 9–10 and at 23–25 years old. At the age of 23–25 years, blood pressure (BP), glycaemia, insulinaemia, homeostasis model assessment – insulin resistance, lipids, fibrinogen, and plasma IGF‐I and 737.738 IGF1 polymorphism were assessed. Results Large for gestational age subjects remained heavier and taller than AGA at 9–10 and 23–25 years (P