Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells

Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells

Drug and heat delivery to tumors by active targeting with Herceptin‐conjugated doxorubicin‐loaded poly(ethylene glycol)–poly(lactic‐co‐glycolic acid)–Au half‐shell nanoparticles (HER‐DOX‐PLGA‐Au H‐S NPs) is more effective than passive targeting with their HER‐free counterparts (DOX‐PLGA‐Au H‐S NPs)....

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Veröffentlicht in:Angewandte Chemie International Edition 2011-08, Vol.50 (33), p.7581-7586
Hauptverfasser: Lee, Sun-Mi, Park, Huiyul, Choi, Joung-Woo, Park, Young Nyun, Yun, Chae-Ok, Yoo, Kyung-Hwa
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Monoclonal, Humanized - chemistry
Antineoplastic Combined Chemotherapy Protocols - chemistry
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Apoptosis - drug effects
cancer
Cell Proliferation - drug effects
chemophotothermal treatment
Dose-Response Relationship, Drug
Doxorubicin - chemistry
Doxorubicin - pharmacology
drug delivery
Female
Gold - chemistry
Hot Temperature
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - therapy
Metal Nanoparticles - chemistry
Mice
Mice, Inbred BALB C
Mice, Nude
nanoparticles
Particle Size
Phototherapy
Polyethylene Glycols - chemistry
Polyglactin 910 - chemistry
Structure-Activity Relationship
Surface Properties
Tissue Distribution
Trastuzumab
Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:Drug and heat delivery to tumors by active targeting with Herceptin‐conjugated doxorubicin‐loaded poly(ethylene glycol)–poly(lactic‐co‐glycolic acid)–Au half‐shell nanoparticles (HER‐DOX‐PLGA‐Au H‐S NPs) is more effective than passive targeting with their HER‐free counterparts (DOX‐PLGA‐Au H‐S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor‐bearing mice that were treated with the HER‐conjugated particles (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201101783