GeT peptides: a single-domain approach to gene delivery

A generic peptide sequence for gene delivery is described. The sequence penetrates eukaryotic cells and promotes active DNA transport into mammalian cells (EGFP positive) by undergoing differential membrane-induced folding, which renders it both endosomolytic and antibacterial.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-08, Vol.47 (32), p.9045-9047
Hauptverfasser:	Lamarre, Baptiste, Ravi, Jascindra, Ryadnov, Maxim G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Cell Membrane Permeability Cells, Cultured DNA - administration & dosage DNA - genetics Fibroblasts - cytology Fibroblasts - metabolism Gene Transfer Techniques Green Fluorescent Proteins - genetics Humans Molecular Sequence Data Peptides - chemistry Peptides - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A generic peptide sequence for gene delivery is described. The sequence penetrates eukaryotic cells and promotes active DNA transport into mammalian cells (EGFP positive) by undergoing differential membrane-induced folding, which renders it both endosomolytic and antibacterial.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc13043a