Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer

Highlights ► We clarified expression and roles of FGFR2 in colorectal cancer. ► The invasive front of colorectal cancer exhibited strong FGFR2 expression. ► Reduced expression of FGFR2 inhibited cell migration, invasion and tumor growth. ► FGFR2 might be a novel therapeutic target for colorectal can...

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Veröffentlicht in:	Cancer letters 2011-10, Vol.309 (2), p.209-219
Hauptverfasser:	Matsuda, Yoko, Ishiwata, Toshiyuki, Yamahatsu, Kazuya, Kawahara, Kiyoko, Hagio, Masahito, Peng, Wei-Xia, Yamamoto, Tetsushi, Nakazawa, Nando, Seya, Tomoko, Ohaki, Yoshiharu, Naito, Zenya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies, Monoclonal Breast cancer Cancer therapies Cell Adhesion Cell growth cell movement Cell Movement - genetics Cell Proliferation Colon Colorectal cancer colorectal neoplasms Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Disease Disease Progression Epidermal growth factor Extracellular Matrix Female Fibroblast growth factor receptor 2 Flow Cytometry Gene amplification Gene expression Gene Expression Regulation, Neoplastic Growth Hematology, Oncology and Palliative Medicine Humans Male Metastasis Mice Mice, Nude Middle Aged Mutation Neoplasm Invasiveness Pathology Polymerase Chain Reaction Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - immunology Receptor, Fibroblast Growth Factor, Type 2 - metabolism RNA Interference RNA, Small Interfering - pharmacology Signal Transduction surface area The invasive front
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Zusammenfassung:	Highlights ► We clarified expression and roles of FGFR2 in colorectal cancer. ► The invasive front of colorectal cancer exhibited strong FGFR2 expression. ► Reduced expression of FGFR2 inhibited cell migration, invasion and tumor growth. ► FGFR2 might be a novel therapeutic target for colorectal cancer.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.06.009