Determining the Relations between Protein Sub-Function Categories Based on Overlapping Proteins

Protein functions and their relations are powerful tasks in the field of proteomics since it can lead to knowing cell functions and activities. The relations between the proteins functions do not be considered into protein function/interaction prediction; although they have critical rule in improvement the accuracy of protein functions. In this paper, we propose a technique for determining the relation between the protein functions. The technique is based on the overlapping number of proteins that to determine the correlation between the sub-function categories as well as improve the protein function prediction process. The proposed method was applied to Yeast functions proteome and the results revealed great improvement in increasing the degree of certainty and accuracy for protein function prediction.