Stereoselective Synthesis of Highly Substituted Enamides by an Oxidative Heck Reaction

Functionalization of enamides under Heck conditions has been limited to those with unsubstituted vinyl groups. By tuning reaction parameters that allow for the balance between stability and reactivity of reactants, the oxidative Heck cross‐coupling to produce highly substituted enamides in good to excellent yields was achieved (see scheme).