Adiponectin is a negative regulator of antigen‐activated T cells

Adiponectin (APN), a cytokine constitutively produced in fat tissue, has been shown to exert anti‐inflammatory effects in various disease models. While the influence of APN on monocytic cells has been extensively studied in vitro, little is known about its role in T cells. In this study, we show tha...

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Veröffentlicht in:	European journal of immunology 2011-08, Vol.41 (8), p.2323-2332
Hauptverfasser:	Wilk, Sabrina, Scheibenbogen, Carmen, Bauer, Sandra, Jenke, Alexander, Rother, Madlen, Guerreiro, Manuel, Kudernatsch, Robert, Goerner, Nicole, Poller, Wolfgang, Elligsen‐Merkel, Diana, Utku, Nalan, Magrane, Jordi, Volk, Hans D., Skurk, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - genetics Adiponectin - immunology Adiponectin - pharmacology Adiponectin receptors Animals Antigens - immunology Antigens, CD - immunology Antigens, CD - metabolism Cell Proliferation - drug effects Cells, Cultured Clathrin-Coated Vesicles - immunology Clathrin-Coated Vesicles - metabolism Coxsackievirus Coxsackievirus Infections - genetics Coxsackievirus Infections - immunology Coxsackievirus Infections - virology CTLA-4 Antigen Flow Cytometry Gene Expression Humans Immunomodulation Interferon-gamma - immunology Interferon-gamma - metabolism Jurkat Cells K562 Cells Lymphocyte Activation - immunology Lymphocytes Male Medical research Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Fluorescence Receptors, Adiponectin - genetics Receptors, Adiponectin - immunology Receptors, Adiponectin - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Vacuolar Proton-Translocating ATPases - immunology Vacuolar Proton-Translocating ATPases - metabolism
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Zusammenfassung:	Adiponectin (APN), a cytokine constitutively produced in fat tissue, has been shown to exert anti‐inflammatory effects in various disease models. While the influence of APN on monocytic cells has been extensively studied in vitro, little is known about its role in T cells. In this study, we show that while
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.201041349