Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

Summary Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91–22·86, n=2063, p...

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Veröffentlicht in:Lancet neurology 2010-09, Vol.9 (9), p.921-932
Hauptverfasser: Petzold, Axel, Dr, de Boer, Johannes F, Prof, Schippling, Sven, MD, Vermersch, Patrik, Prof, Kardon, Randy, Prof, Green, Ari, MD, Calabresi, Peter A, Prof, Polman, Chris, Prof
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Algorithms
Data processing
Fluorescence
Humans
Meta-Analysis as Topic
Models, Biological
Multiple sclerosis
Multiple Sclerosis - diagnosis
Nerves
Neurodegeneration
Neurology
Optic neuritis
Retina
Retina - pathology
Retinal ganglion cells
Reviews
Segmentation
Structure-function relationships
Systematic review
Thinning
Tomography
Tomography, Optical Coherence - methods
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Zusammenfassung:Summary Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91–22·86, n=2063, p
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(10)70168-X