Triclosan - an update
The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induc...
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| Veröffentlicht in: | Letters in applied microbiology 2011-02, Vol.52 (2), p.87-95 |
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| container_end_page | 95 |
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| container_issue | 2 |
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| container_title | Letters in applied microbiology |
| container_volume | 52 |
| creator | Saleh, S Haddadin, R.N.S Baillie, S Collier, P.J |
| description | The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic. |
| doi_str_mv | 10.1111/j.1472-765X.2010.02976.x |
| format | Article |
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Psychology</subject><subject>mechanism of action</subject><subject>Microbiology</subject><subject>resistance</subject><subject>Triclosan - chemistry</subject><subject>Triclosan - pharmacology</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL1PAjEchhujEURHV2UxTof99fM6OBDiV4JxEBK3pty15sjBYctF-O_teYijdmib9nnfNg9CfcADiONmPgAmSSIFfxsQHE8xUVIMNgeou784RF1MhEhSwlkHnYQwxxinQNQx6hAAIVIKXXQ-8UVWVsEs-0k_TvUqN2t7io6cKYM92609NL2_m4wek_HLw9NoOE4yjplIOJfCKqcccI5NbMQuNTNHs1xZKhSklBgKxGJHKGOQOU4gB-cIngFIwmgPXbe9K1991Das9aIImS1Ls7RVHXQqFZNAU_w3SXmsFEJGMm3JzFcheOv0yhcL47casG7s6bluJOlGkm7s6W97ehOjF7tH6tnC5vvgj64IXO0AEzJTOm-WWRF-OSopjmzkblvusyjt9t8f0OPhc7OL-cs270ylzbuPb0xfIxnbFcWcSfoFx9aP6Q</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Saleh, S</creator><creator>Haddadin, R.N.S</creator><creator>Baillie, S</creator><creator>Collier, P.J</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201102</creationdate><title>Triclosan - an update</title><author>Saleh, S ; Haddadin, R.N.S ; Baillie, S ; Collier, P.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5046-5576e9f9f1550a6680f8abf3cd9e3691832a312e0f23441cf521d1ff20b117243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>antibiotics</topic><topic>antimicrobials</topic><topic>biocides</topic><topic>Biological and medical sciences</topic><topic>Disinfectants - chemistry</topic><topic>Disinfectants - pharmacology</topic><topic>Drug Resistance, Bacterial</topic><topic>Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) - antagonists & inhibitors</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fatty Acid Synthesis Inhibitors - chemistry</topic><topic>Fatty Acid Synthesis Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0266-8254 |
| ispartof | Letters in applied microbiology, 2011-02, Vol.52 (2), p.87-95 |
| issn | 0266-8254 1472-765X |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | antibiotics antimicrobials biocides Biological and medical sciences Disinfectants - chemistry Disinfectants - pharmacology Drug Resistance, Bacterial Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) - antagonists & inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fatty Acid Synthesis Inhibitors - chemistry Fatty Acid Synthesis Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology mechanism of action Microbiology resistance Triclosan - chemistry Triclosan - pharmacology |
| title | Triclosan - an update |
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