Triclosan - an update

The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induc...

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Veröffentlicht in:	Letters in applied microbiology 2011-02, Vol.52 (2), p.87-95
Hauptverfasser:	Saleh, S, Haddadin, R.N.S, Baillie, S, Collier, P.J
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics antimicrobials biocides Biological and medical sciences Disinfectants - chemistry Disinfectants - pharmacology Drug Resistance, Bacterial Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) - antagonists & inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fatty Acid Synthesis Inhibitors - chemistry Fatty Acid Synthesis Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology mechanism of action Microbiology resistance Triclosan - chemistry Triclosan - pharmacology
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Beschreibung
Zusammenfassung:	The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.
ISSN:	0266-8254 1472-765X
DOI:	10.1111/j.1472-765X.2010.02976.x