Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC

Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds. A traditional mastic named yakı sakızı prepared from the...

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Veröffentlicht in:Journal of ethnopharmacology 2010-08, Vol.131 (1), p.83-87
Hauptverfasser: Bahadır, Özlem, Çitoğlu, Gülçin Saltan, Šmejkal, Karel, Dall’Acqua, Stefano, Özbek, Hanefi, Cvacka, Josef, Zemlicka, Milan
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container_issue 1
container_start_page 83
container_title Journal of ethnopharmacology
container_volume 131
creator Bahadır, Özlem
Çitoğlu, Gülçin Saltan
Šmejkal, Karel
Dall’Acqua, Stefano
Özbek, Hanefi
Cvacka, Josef
Zemlicka, Milan
description Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds. A traditional mastic named yakı sakızı prepared from the roots of Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine. To isolate and identify the compounds responsible for the antinociceptive activity of S. latifolia using bioassay-guided fractionation. The methanolic extract of the S. latifolia roots was prepared and subjected to isolation procedures such as solvent–solvent partitioning and column chromatography. Writhing and tail-flick tests were used to determine the antinociceptive activity. The n-hexane fraction of the S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds. Results of the present study support the usage of S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds.
doi_str_mv 10.1016/j.jep.2010.06.003
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The n-hexane fraction of the S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds. Results of the present study support the usage of S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. 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DC</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2010-08-19</date><risdate>2010</risdate><volume>131</volume><issue>1</issue><spage>83</spage><epage>87</epage><pages>83-87</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds. A traditional mastic named yakı sakızı prepared from the roots of Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine. To isolate and identify the compounds responsible for the antinociceptive activity of S. latifolia using bioassay-guided fractionation. 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Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20541001</pmid><doi>10.1016/j.jep.2010.06.003</doi><tpages>5</tpages></addata></record>
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subjects Analgesic activity
analgesic effect
Analgesics - chemistry
Analgesics - isolation & purification
Analgesics - pharmacology
animal models
Animals
Biological and medical sciences
chemical structure
Chromatography
dosage
dose response
Fern-7-en-3-β-one
fractionation
General pharmacology
gums
Male
mass spectrometry
Medical sciences
medicinal plants
Mice
Mice, Inbred BALB C
nuclear magnetic resonance spectroscopy
Pain Measurement - drug effects
Pain Measurement - methods
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant extracts
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Roots
roots
Scorzonera
Scorzonera latifolia
solvents
synergism
Taraxasteryl acetate
Taraxasteryl myristate
Triterpenes
triterpenoids
title Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC
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