Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC
Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds. A traditional mastic named yakı sakızı prepared from the...
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container_title | Journal of ethnopharmacology |
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creator | Bahadır, Özlem Çitoğlu, Gülçin Saltan Šmejkal, Karel Dall’Acqua, Stefano Özbek, Hanefi Cvacka, Josef Zemlicka, Milan |
description | Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of
Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds.
A traditional mastic named
yakı sakızı prepared from the roots of
Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine.
To isolate and identify the compounds responsible for the antinociceptive activity of
S. latifolia using bioassay-guided fractionation.
The methanolic extract of the
S. latifolia roots was prepared and subjected to isolation procedures such as solvent–solvent partitioning and column chromatography. Writhing and tail-flick tests were used to determine the antinociceptive activity.
The
n-hexane fraction of the
S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from
n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds.
Results of the present study support the usage of
S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds. |
doi_str_mv | 10.1016/j.jep.2010.06.003 |
format | Article |
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Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds.
A traditional mastic named
yakı sakızı prepared from the roots of
Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine.
To isolate and identify the compounds responsible for the antinociceptive activity of
S. latifolia using bioassay-guided fractionation.
The methanolic extract of the
S. latifolia roots was prepared and subjected to isolation procedures such as solvent–solvent partitioning and column chromatography. Writhing and tail-flick tests were used to determine the antinociceptive activity.
The
n-hexane fraction of the
S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from
n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds.
Results of the present study support the usage of
S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2010.06.003</identifier><identifier>PMID: 20541001</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analgesic activity ; analgesic effect ; Analgesics - chemistry ; Analgesics - isolation & purification ; Analgesics - pharmacology ; animal models ; Animals ; Biological and medical sciences ; chemical structure ; Chromatography ; dosage ; dose response ; Fern-7-en-3-β-one ; fractionation ; General pharmacology ; gums ; Male ; mass spectrometry ; Medical sciences ; medicinal plants ; Mice ; Mice, Inbred BALB C ; nuclear magnetic resonance spectroscopy ; Pain Measurement - drug effects ; Pain Measurement - methods ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots ; roots ; Scorzonera ; Scorzonera latifolia ; solvents ; synergism ; Taraxasteryl acetate ; Taraxasteryl myristate ; Triterpenes ; triterpenoids</subject><ispartof>Journal of ethnopharmacology, 2010-08, Vol.131 (1), p.83-87</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e44ff69c12038f109ccc03bbba39dca1d9cd3f12849f131240898522542639743</citedby><cites>FETCH-LOGICAL-c438t-e44ff69c12038f109ccc03bbba39dca1d9cd3f12849f131240898522542639743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874110003880$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23154118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20541001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahadır, Özlem</creatorcontrib><creatorcontrib>Çitoğlu, Gülçin Saltan</creatorcontrib><creatorcontrib>Šmejkal, Karel</creatorcontrib><creatorcontrib>Dall’Acqua, Stefano</creatorcontrib><creatorcontrib>Özbek, Hanefi</creatorcontrib><creatorcontrib>Cvacka, Josef</creatorcontrib><creatorcontrib>Zemlicka, Milan</creatorcontrib><title>Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of
Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds.
A traditional mastic named
yakı sakızı prepared from the roots of
Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine.
To isolate and identify the compounds responsible for the antinociceptive activity of
S. latifolia using bioassay-guided fractionation.
The methanolic extract of the
S. latifolia roots was prepared and subjected to isolation procedures such as solvent–solvent partitioning and column chromatography. Writhing and tail-flick tests were used to determine the antinociceptive activity.
The
n-hexane fraction of the
S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from
n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds.
Results of the present study support the usage of
S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds.</description><subject>Analgesic activity</subject><subject>analgesic effect</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - isolation & purification</subject><subject>Analgesics - pharmacology</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>Chromatography</subject><subject>dosage</subject><subject>dose response</subject><subject>Fern-7-en-3-β-one</subject><subject>fractionation</subject><subject>General pharmacology</subject><subject>gums</subject><subject>Male</subject><subject>mass spectrometry</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Measurement - methods</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>roots</subject><subject>Scorzonera</subject><subject>Scorzonera latifolia</subject><subject>solvents</subject><subject>synergism</subject><subject>Taraxasteryl acetate</subject><subject>Taraxasteryl myristate</subject><subject>Triterpenes</subject><subject>triterpenoids</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1OGzEUBWALFUGgPACbdjZV28VM77Wdsa2uaMpPJRALytpyPDZ1NDMOdoJEnx5HSdtdWVmWvnt8dUzIKUKDgO2XRbNwy4ZCuUPbALA9MkEpaC2mgr0hE2BC1lJwPCRHOS8AQCCHA3JIYcoRACfk29lo-geXg61sHJZxPXa58ikO1Z2N6XccXTJVb1bBxz6Y6tNFyPZXU5mxq27cc_O5-j57S_a96bM72Z3H5P7i_Ofsqr6-vfwxO7uuLWdyVTvOvW-VRQpMegRlrQU2n88NU5012CnbMY9UcuWRIeUglZxSOuW0ZUpwdkw-bnOXKT6uXV7poSzj-t6MLq6zlkLxVkkBr0rBpdrEtkXiVtoUc07O62UKg0nPGkFvOtYLXTrWm441tLp0XGbe7dLX88F1fyf-lFrAhx0w2ZreJzPakP85hgWiLO791nkTtXlIxdzflZcYlE8UTG7E161wpden4JLONrjRui4kZ1e6i-E_i74AD8yfDQ</recordid><startdate>20100819</startdate><enddate>20100819</enddate><creator>Bahadır, Özlem</creator><creator>Çitoğlu, Gülçin Saltan</creator><creator>Šmejkal, Karel</creator><creator>Dall’Acqua, Stefano</creator><creator>Özbek, Hanefi</creator><creator>Cvacka, Josef</creator><creator>Zemlicka, Milan</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20100819</creationdate><title>Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC</title><author>Bahadır, Özlem ; Çitoğlu, Gülçin Saltan ; Šmejkal, Karel ; Dall’Acqua, Stefano ; Özbek, Hanefi ; Cvacka, Josef ; Zemlicka, Milan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e44ff69c12038f109ccc03bbba39dca1d9cd3f12849f131240898522542639743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analgesic activity</topic><topic>analgesic effect</topic><topic>Analgesics - chemistry</topic><topic>Analgesics - isolation & purification</topic><topic>Analgesics - pharmacology</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>Chromatography</topic><topic>dosage</topic><topic>dose response</topic><topic>Fern-7-en-3-β-one</topic><topic>fractionation</topic><topic>General pharmacology</topic><topic>gums</topic><topic>Male</topic><topic>mass spectrometry</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Measurement - methods</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>roots</topic><topic>Scorzonera</topic><topic>Scorzonera latifolia</topic><topic>solvents</topic><topic>synergism</topic><topic>Taraxasteryl acetate</topic><topic>Taraxasteryl myristate</topic><topic>Triterpenes</topic><topic>triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahadır, Özlem</creatorcontrib><creatorcontrib>Çitoğlu, Gülçin Saltan</creatorcontrib><creatorcontrib>Šmejkal, Karel</creatorcontrib><creatorcontrib>Dall’Acqua, Stefano</creatorcontrib><creatorcontrib>Özbek, Hanefi</creatorcontrib><creatorcontrib>Cvacka, Josef</creatorcontrib><creatorcontrib>Zemlicka, Milan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahadır, Özlem</au><au>Çitoğlu, Gülçin Saltan</au><au>Šmejkal, Karel</au><au>Dall’Acqua, Stefano</au><au>Özbek, Hanefi</au><au>Cvacka, Josef</au><au>Zemlicka, Milan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2010-08-19</date><risdate>2010</risdate><volume>131</volume><issue>1</issue><spage>83</spage><epage>87</epage><pages>83-87</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Two taraxasterol derivatives, taraxasteryl myristate and taraxasteryl acetate, were isolated from the methanolic extract of
Scorzonera latifolia (Fisch. and Mey.) DC. using bioassay guided fractionation as an antinociceptive active compounds.
A traditional mastic named
yakı sakızı prepared from the roots of
Scorzonera latifolia (Fisch. and Mey.) DC. is used as a folk remedy for treatment of pain in Turkish folk medicine.
To isolate and identify the compounds responsible for the antinociceptive activity of
S. latifolia using bioassay-guided fractionation.
The methanolic extract of the
S. latifolia roots was prepared and subjected to isolation procedures such as solvent–solvent partitioning and column chromatography. Writhing and tail-flick tests were used to determine the antinociceptive activity.
The
n-hexane fraction of the
S. latifolia root methanolic extract showed potent antinociceptive activity in both writhing and tail-flick tests. Three compounds were isolated from
n-hexane fraction using bioassay-guided chromatographic purification. Isolated compounds were the triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-β-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds.
Results of the present study support the usage of
S. latifolia in Turkish folk medicine. Both plant root extract and the isolated compounds showed promising antinociceptive activities. Our results suggested that antinociceptive activity of the plant extract is probably caused by the synergistic interaction of the isolated compounds.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20541001</pmid><doi>10.1016/j.jep.2010.06.003</doi><tpages>5</tpages></addata></record> |
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subjects | Analgesic activity analgesic effect Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology animal models Animals Biological and medical sciences chemical structure Chromatography dosage dose response Fern-7-en-3-β-one fractionation General pharmacology gums Male mass spectrometry Medical sciences medicinal plants Mice Mice, Inbred BALB C nuclear magnetic resonance spectroscopy Pain Measurement - drug effects Pain Measurement - methods Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots roots Scorzonera Scorzonera latifolia solvents synergism Taraxasteryl acetate Taraxasteryl myristate Triterpenes triterpenoids |
title | Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC |
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