Dietary α-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation

OBJECTIVE—Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. METHODS AND RESULTS—Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-08, Vol.31 (8), p.1772-1780
Hauptverfasser:	Holy, Erik W, Forestier, Marc, Richter, Eva K, Akhmedov, Alexander, Leiber, Florian, Camici, Giovanni G, Mocharla, Pavani, Lüscher, Thomas F, Beer, Jürg H, Tanner, Felix C
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Linolenic Acid - administration & dosage Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiotonic Agents - administration & dosage Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Artery Thrombosis - blood Carotid Artery Thrombosis - metabolism Carotid Artery Thrombosis - prevention & control Cells, Cultured Dietary Supplements Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Cells - drug effects Endothelial Cells - metabolism Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Humans Male MAP Kinase Kinase Kinase 5 - metabolism MAP Kinase Signaling System - drug effects Medical sciences Mice Mice, Inbred C57BL Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Platelet Activation - drug effects Platelet Aggregation - drug effects Thromboplastin - genetics Thromboplastin - metabolism Tumor Necrosis Factor-alpha - pharmacology Vertebrates: cardiovascular system
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Zusammenfassung:	OBJECTIVE—Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. METHODS AND RESULTS—Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial thrombus formation was delayed in mice fed a high-ALA diet compared with those on a low-ALA diet (n=7; P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.111.226118