Piperazic acid-containing natural products: isolation, biological relevance and total synthesis

Piperazic acid-containing natural products: isolation, biological relevance and total synthesis

Since their first discovery in 1959, natural products containing the piperazic acid motif have been isolated from a variety of sources and exhibit diverse biological activity profiles. This review provides information about their isolation and biological activities, and presents an overview of recen...

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Veröffentlicht in:Natural product reports 2011-08, Vol.28 (8), p.1445-1471
Hauptverfasser: Oelke, Alexander J, France, David J, Hofmann, Tatjana, Wuitschik, Georg, Ley, Steven V
Format: Artikel
Sprache:eng
Schlagworte:
Biological Products - chemical synthesis
Biological Products - isolation & purification
Biological Products - pharmacology
Molecular Structure
Pyridazines - chemical synthesis
Pyridazines - chemistry
Pyridazines - pharmacology
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Zusammenfassung:Since their first discovery in 1959, natural products containing the piperazic acid motif have been isolated from a variety of sources and exhibit diverse biological activity profiles. This review provides information about their isolation and biological activities, and presents an overview of recent total syntheses of these molecules.
ISSN:0265-0568
1460-4752
DOI:10.1039/c1np00041a