Biomarkers of Over‐Immunosuppression

An important goal in transplantation is to tailor immunosuppression to the individual needs of the patient, avoiding both rejection and over‐immunosuppression. Opportunistic infections and malignancies remain a significant cause of death after transplantation and are obvious consequences of over‐imm...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2011-08, Vol.90 (2), p.316-322
Hauptverfasser:	Budde, K, Matz, M, Dürr, M, Glander, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Pharmacological - metabolism Drug Monitoring - methods Graft Rejection - prevention & control Humans Immunosuppression - methods Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Medical sciences Opportunistic Infections - etiology Opportunistic Infections - prevention & control Organ Transplantation - methods Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	An important goal in transplantation is to tailor immunosuppression to the individual needs of the patient, avoiding both rejection and over‐immunosuppression. Opportunistic infections and malignancies remain a significant cause of death after transplantation and are obvious consequences of over‐immunosuppression. Currently, monitoring of immunosuppression is conducted mainly on the basis of pharmacokinetic characteristics, which do not necessarily predict clinical outcome in the individual. This review focuses on the potential of using biomarkers as a monitoring tool to prevent over‐immunosuppression after transplantation. Clinical Pharmacology & Therapeutics (2011) 90 2, 316–322. doi:10.1038/clpt.2011.111
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2011.111