Full Face Transplant: The First Case Report

Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the sof...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of surgery 2011-08, Vol.254 (2), p.252-256
Hauptverfasser: BARRET, Juan P, GAVALDA, Joan, COLLADO, Jose M, SALAMERO, Pere, MORENO, Carlos, DEULOFEU, Roser, MARTINEZ-IBANEZ, Vicenç, BUENO, Javier, NUVIALS, Xavier, PONT, Teresa, MASNOU, Nuria, COLOMINA, Maria J, SERRACANTA, Jordi, ARNO, Anna, HUGUET, Pere
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 256
container_issue 2
container_start_page 252
container_title Annals of surgery
container_volume 254
creator BARRET, Juan P
GAVALDA, Joan
COLLADO, Jose M
SALAMERO, Pere
MORENO, Carlos
DEULOFEU, Roser
MARTINEZ-IBANEZ, Vicenç
BUENO, Javier
NUVIALS, Xavier
PONT, Teresa
MASNOU, Nuria
COLOMINA, Maria J
SERRACANTA, Jordi
ARNO, Anna
HUGUET, Pere
description Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole). There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance. The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.
doi_str_mv 10.1097/SLA.0b013e318226a607
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_878593631</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>878593631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c285t-42a9ea569ef6c4fbe4b14653643de908fa89458f3e7b3b8ffd0eb82bbb87d7ef3</originalsourceid><addsrcrecordid>eNpdkE1Lw0AURQdRbK3-A5FsxIWkvvnIzMRdKUaFgqB1HWYmbzCSNnEmWfjvjbQquLqbc9-7HELOKcwp5OrmZbWYgwXKkVPNmDQS1AGZ0ozplFIBh2QKADwVOWcTchLjOwAVGtQxmTCqFKNMTsl1MTRNUhiHyTqYbewas-1vk_UbJkUdYp8sTcTkGbs29KfkyJsm4tk-Z-S1uFsvH9LV0_3jcrFKHdNZnwpmcjSZzNFLJ7xFYamQGZeCV5iD9kbnItOeo7Lcau8rQKuZtVarSqHnM3K1u9uF9mPA2JebOjpsxmnYDrHUSmc5l5yOpNiRLrQxBvRlF-qNCZ8lhfLbUjlaKv9bGmsX-weD3WD1W_rRMgKXe8BEZxo_mnF1_OME14LyjH8Br2Bu-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>878593631</pqid></control><display><type>article</type><title>Full Face Transplant: The First Case Report</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>PubMed Central</source><creator>BARRET, Juan P ; GAVALDA, Joan ; COLLADO, Jose M ; SALAMERO, Pere ; MORENO, Carlos ; DEULOFEU, Roser ; MARTINEZ-IBANEZ, Vicenç ; BUENO, Javier ; NUVIALS, Xavier ; PONT, Teresa ; MASNOU, Nuria ; COLOMINA, Maria J ; SERRACANTA, Jordi ; ARNO, Anna ; HUGUET, Pere</creator><creatorcontrib>BARRET, Juan P ; GAVALDA, Joan ; COLLADO, Jose M ; SALAMERO, Pere ; MORENO, Carlos ; DEULOFEU, Roser ; MARTINEZ-IBANEZ, Vicenç ; BUENO, Javier ; NUVIALS, Xavier ; PONT, Teresa ; MASNOU, Nuria ; COLOMINA, Maria J ; SERRACANTA, Jordi ; ARNO, Anna ; HUGUET, Pere</creatorcontrib><description>Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole). There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance. The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/SLA.0b013e318226a607</identifier><identifier>PMID: 21772126</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Drug Therapy, Combination ; Esthetics ; Facial Injuries - surgery ; Facial Transplantation - methods ; Feasibility Studies ; General aspects ; Graft Rejection - drug therapy ; Humans ; Immunosuppressive Agents - administration &amp; dosage ; Male ; Medical sciences ; Microsurgery - methods ; Patient Satisfaction ; Postoperative Care ; Postoperative Complications - etiology ; Postoperative Complications - surgery ; Reoperation ; Spain ; Tissue and Organ Harvesting - methods ; Tissue Donors ; Transplantation, Homologous ; Wound Healing - physiology ; Wounds, Gunshot - surgery</subject><ispartof>Annals of surgery, 2011-08, Vol.254 (2), p.252-256</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c285t-42a9ea569ef6c4fbe4b14653643de908fa89458f3e7b3b8ffd0eb82bbb87d7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24384135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21772126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARRET, Juan P</creatorcontrib><creatorcontrib>GAVALDA, Joan</creatorcontrib><creatorcontrib>COLLADO, Jose M</creatorcontrib><creatorcontrib>SALAMERO, Pere</creatorcontrib><creatorcontrib>MORENO, Carlos</creatorcontrib><creatorcontrib>DEULOFEU, Roser</creatorcontrib><creatorcontrib>MARTINEZ-IBANEZ, Vicenç</creatorcontrib><creatorcontrib>BUENO, Javier</creatorcontrib><creatorcontrib>NUVIALS, Xavier</creatorcontrib><creatorcontrib>PONT, Teresa</creatorcontrib><creatorcontrib>MASNOU, Nuria</creatorcontrib><creatorcontrib>COLOMINA, Maria J</creatorcontrib><creatorcontrib>SERRACANTA, Jordi</creatorcontrib><creatorcontrib>ARNO, Anna</creatorcontrib><creatorcontrib>HUGUET, Pere</creatorcontrib><title>Full Face Transplant: The First Case Report</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole). There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance. The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Esthetics</subject><subject>Facial Injuries - surgery</subject><subject>Facial Transplantation - methods</subject><subject>Feasibility Studies</subject><subject>General aspects</subject><subject>Graft Rejection - drug therapy</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration &amp; dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsurgery - methods</subject><subject>Patient Satisfaction</subject><subject>Postoperative Care</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - surgery</subject><subject>Reoperation</subject><subject>Spain</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><subject>Wound Healing - physiology</subject><subject>Wounds, Gunshot - surgery</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AURQdRbK3-A5FsxIWkvvnIzMRdKUaFgqB1HWYmbzCSNnEmWfjvjbQquLqbc9-7HELOKcwp5OrmZbWYgwXKkVPNmDQS1AGZ0ozplFIBh2QKADwVOWcTchLjOwAVGtQxmTCqFKNMTsl1MTRNUhiHyTqYbewas-1vk_UbJkUdYp8sTcTkGbs29KfkyJsm4tk-Z-S1uFsvH9LV0_3jcrFKHdNZnwpmcjSZzNFLJ7xFYamQGZeCV5iD9kbnItOeo7Lcau8rQKuZtVarSqHnM3K1u9uF9mPA2JebOjpsxmnYDrHUSmc5l5yOpNiRLrQxBvRlF-qNCZ8lhfLbUjlaKv9bGmsX-weD3WD1W_rRMgKXe8BEZxo_mnF1_OME14LyjH8Br2Bu-g</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>BARRET, Juan P</creator><creator>GAVALDA, Joan</creator><creator>COLLADO, Jose M</creator><creator>SALAMERO, Pere</creator><creator>MORENO, Carlos</creator><creator>DEULOFEU, Roser</creator><creator>MARTINEZ-IBANEZ, Vicenç</creator><creator>BUENO, Javier</creator><creator>NUVIALS, Xavier</creator><creator>PONT, Teresa</creator><creator>MASNOU, Nuria</creator><creator>COLOMINA, Maria J</creator><creator>SERRACANTA, Jordi</creator><creator>ARNO, Anna</creator><creator>HUGUET, Pere</creator><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Full Face Transplant: The First Case Report</title><author>BARRET, Juan P ; GAVALDA, Joan ; COLLADO, Jose M ; SALAMERO, Pere ; MORENO, Carlos ; DEULOFEU, Roser ; MARTINEZ-IBANEZ, Vicenç ; BUENO, Javier ; NUVIALS, Xavier ; PONT, Teresa ; MASNOU, Nuria ; COLOMINA, Maria J ; SERRACANTA, Jordi ; ARNO, Anna ; HUGUET, Pere</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-42a9ea569ef6c4fbe4b14653643de908fa89458f3e7b3b8ffd0eb82bbb87d7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Esthetics</topic><topic>Facial Injuries - surgery</topic><topic>Facial Transplantation - methods</topic><topic>Feasibility Studies</topic><topic>General aspects</topic><topic>Graft Rejection - drug therapy</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration &amp; dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsurgery - methods</topic><topic>Patient Satisfaction</topic><topic>Postoperative Care</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - surgery</topic><topic>Reoperation</topic><topic>Spain</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><topic>Wound Healing - physiology</topic><topic>Wounds, Gunshot - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARRET, Juan P</creatorcontrib><creatorcontrib>GAVALDA, Joan</creatorcontrib><creatorcontrib>COLLADO, Jose M</creatorcontrib><creatorcontrib>SALAMERO, Pere</creatorcontrib><creatorcontrib>MORENO, Carlos</creatorcontrib><creatorcontrib>DEULOFEU, Roser</creatorcontrib><creatorcontrib>MARTINEZ-IBANEZ, Vicenç</creatorcontrib><creatorcontrib>BUENO, Javier</creatorcontrib><creatorcontrib>NUVIALS, Xavier</creatorcontrib><creatorcontrib>PONT, Teresa</creatorcontrib><creatorcontrib>MASNOU, Nuria</creatorcontrib><creatorcontrib>COLOMINA, Maria J</creatorcontrib><creatorcontrib>SERRACANTA, Jordi</creatorcontrib><creatorcontrib>ARNO, Anna</creatorcontrib><creatorcontrib>HUGUET, Pere</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARRET, Juan P</au><au>GAVALDA, Joan</au><au>COLLADO, Jose M</au><au>SALAMERO, Pere</au><au>MORENO, Carlos</au><au>DEULOFEU, Roser</au><au>MARTINEZ-IBANEZ, Vicenç</au><au>BUENO, Javier</au><au>NUVIALS, Xavier</au><au>PONT, Teresa</au><au>MASNOU, Nuria</au><au>COLOMINA, Maria J</au><au>SERRACANTA, Jordi</au><au>ARNO, Anna</au><au>HUGUET, Pere</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Full Face Transplant: The First Case Report</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>254</volume><issue>2</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole). There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance. The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>21772126</pmid><doi>10.1097/SLA.0b013e318226a607</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0003-4932
ispartof Annals of surgery, 2011-08, Vol.254 (2), p.252-256
issn 0003-4932
1528-1140
language eng
recordid cdi_proquest_miscellaneous_878593631
source Journals@Ovid Ovid Autoload; MEDLINE; PubMed Central
subjects Adult
Biological and medical sciences
Drug Therapy, Combination
Esthetics
Facial Injuries - surgery
Facial Transplantation - methods
Feasibility Studies
General aspects
Graft Rejection - drug therapy
Humans
Immunosuppressive Agents - administration & dosage
Male
Medical sciences
Microsurgery - methods
Patient Satisfaction
Postoperative Care
Postoperative Complications - etiology
Postoperative Complications - surgery
Reoperation
Spain
Tissue and Organ Harvesting - methods
Tissue Donors
Transplantation, Homologous
Wound Healing - physiology
Wounds, Gunshot - surgery
title Full Face Transplant: The First Case Report
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T18%3A30%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Full%20Face%20Transplant:%20The%20First%20Case%20Report&rft.jtitle=Annals%20of%20surgery&rft.au=BARRET,%20Juan%20P&rft.date=2011-08-01&rft.volume=254&rft.issue=2&rft.spage=252&rft.epage=256&rft.pages=252-256&rft.issn=0003-4932&rft.eissn=1528-1140&rft.coden=ANSUA5&rft_id=info:doi/10.1097/SLA.0b013e318226a607&rft_dat=%3Cproquest_cross%3E878593631%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=878593631&rft_id=info:pmid/21772126&rfr_iscdi=true