Full Face Transplant: The First Case Report
Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units. On March 27, 2010, we performed a full face transplant, including all the sof...
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Veröffentlicht in: | Annals of surgery 2011-08, Vol.254 (2), p.252-256 |
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creator | BARRET, Juan P GAVALDA, Joan COLLADO, Jose M SALAMERO, Pere MORENO, Carlos DEULOFEU, Roser MARTINEZ-IBANEZ, Vicenç BUENO, Javier NUVIALS, Xavier PONT, Teresa MASNOU, Nuria COLOMINA, Maria J SERRACANTA, Jordi ARNO, Anna HUGUET, Pere |
description | Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units.
On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole).
There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance.
The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact. |
doi_str_mv | 10.1097/SLA.0b013e318226a607 |
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On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole).
There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance.
The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/SLA.0b013e318226a607</identifier><identifier>PMID: 21772126</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Drug Therapy, Combination ; Esthetics ; Facial Injuries - surgery ; Facial Transplantation - methods ; Feasibility Studies ; General aspects ; Graft Rejection - drug therapy ; Humans ; Immunosuppressive Agents - administration & dosage ; Male ; Medical sciences ; Microsurgery - methods ; Patient Satisfaction ; Postoperative Care ; Postoperative Complications - etiology ; Postoperative Complications - surgery ; Reoperation ; Spain ; Tissue and Organ Harvesting - methods ; Tissue Donors ; Transplantation, Homologous ; Wound Healing - physiology ; Wounds, Gunshot - surgery</subject><ispartof>Annals of surgery, 2011-08, Vol.254 (2), p.252-256</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c285t-42a9ea569ef6c4fbe4b14653643de908fa89458f3e7b3b8ffd0eb82bbb87d7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24384135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21772126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARRET, Juan P</creatorcontrib><creatorcontrib>GAVALDA, Joan</creatorcontrib><creatorcontrib>COLLADO, Jose M</creatorcontrib><creatorcontrib>SALAMERO, Pere</creatorcontrib><creatorcontrib>MORENO, Carlos</creatorcontrib><creatorcontrib>DEULOFEU, Roser</creatorcontrib><creatorcontrib>MARTINEZ-IBANEZ, Vicenç</creatorcontrib><creatorcontrib>BUENO, Javier</creatorcontrib><creatorcontrib>NUVIALS, Xavier</creatorcontrib><creatorcontrib>PONT, Teresa</creatorcontrib><creatorcontrib>MASNOU, Nuria</creatorcontrib><creatorcontrib>COLOMINA, Maria J</creatorcontrib><creatorcontrib>SERRACANTA, Jordi</creatorcontrib><creatorcontrib>ARNO, Anna</creatorcontrib><creatorcontrib>HUGUET, Pere</creatorcontrib><title>Full Face Transplant: The First Case Report</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units.
On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole).
There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance.
The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Esthetics</subject><subject>Facial Injuries - surgery</subject><subject>Facial Transplantation - methods</subject><subject>Feasibility Studies</subject><subject>General aspects</subject><subject>Graft Rejection - drug therapy</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsurgery - methods</subject><subject>Patient Satisfaction</subject><subject>Postoperative Care</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - surgery</subject><subject>Reoperation</subject><subject>Spain</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><subject>Wound Healing - physiology</subject><subject>Wounds, Gunshot - surgery</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AURQdRbK3-A5FsxIWkvvnIzMRdKUaFgqB1HWYmbzCSNnEmWfjvjbQquLqbc9-7HELOKcwp5OrmZbWYgwXKkVPNmDQS1AGZ0ozplFIBh2QKADwVOWcTchLjOwAVGtQxmTCqFKNMTsl1MTRNUhiHyTqYbewas-1vk_UbJkUdYp8sTcTkGbs29KfkyJsm4tk-Z-S1uFsvH9LV0_3jcrFKHdNZnwpmcjSZzNFLJ7xFYamQGZeCV5iD9kbnItOeo7Lcau8rQKuZtVarSqHnM3K1u9uF9mPA2JebOjpsxmnYDrHUSmc5l5yOpNiRLrQxBvRlF-qNCZ8lhfLbUjlaKv9bGmsX-weD3WD1W_rRMgKXe8BEZxo_mnF1_OME14LyjH8Br2Bu-g</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>BARRET, Juan P</creator><creator>GAVALDA, Joan</creator><creator>COLLADO, Jose M</creator><creator>SALAMERO, Pere</creator><creator>MORENO, Carlos</creator><creator>DEULOFEU, Roser</creator><creator>MARTINEZ-IBANEZ, Vicenç</creator><creator>BUENO, Javier</creator><creator>NUVIALS, Xavier</creator><creator>PONT, Teresa</creator><creator>MASNOU, Nuria</creator><creator>COLOMINA, Maria J</creator><creator>SERRACANTA, Jordi</creator><creator>ARNO, Anna</creator><creator>HUGUET, Pere</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Full Face Transplant: The First Case Report</title><author>BARRET, Juan P ; GAVALDA, Joan ; COLLADO, Jose M ; SALAMERO, Pere ; MORENO, Carlos ; DEULOFEU, Roser ; MARTINEZ-IBANEZ, Vicenç ; BUENO, Javier ; NUVIALS, Xavier ; PONT, Teresa ; MASNOU, Nuria ; COLOMINA, Maria J ; SERRACANTA, Jordi ; ARNO, Anna ; HUGUET, Pere</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-42a9ea569ef6c4fbe4b14653643de908fa89458f3e7b3b8ffd0eb82bbb87d7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Esthetics</topic><topic>Facial Injuries - surgery</topic><topic>Facial Transplantation - methods</topic><topic>Feasibility Studies</topic><topic>General aspects</topic><topic>Graft Rejection - drug therapy</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsurgery - methods</topic><topic>Patient Satisfaction</topic><topic>Postoperative Care</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - surgery</topic><topic>Reoperation</topic><topic>Spain</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><topic>Wound Healing - physiology</topic><topic>Wounds, Gunshot - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARRET, Juan P</creatorcontrib><creatorcontrib>GAVALDA, Joan</creatorcontrib><creatorcontrib>COLLADO, Jose M</creatorcontrib><creatorcontrib>SALAMERO, Pere</creatorcontrib><creatorcontrib>MORENO, Carlos</creatorcontrib><creatorcontrib>DEULOFEU, Roser</creatorcontrib><creatorcontrib>MARTINEZ-IBANEZ, Vicenç</creatorcontrib><creatorcontrib>BUENO, Javier</creatorcontrib><creatorcontrib>NUVIALS, Xavier</creatorcontrib><creatorcontrib>PONT, Teresa</creatorcontrib><creatorcontrib>MASNOU, Nuria</creatorcontrib><creatorcontrib>COLOMINA, Maria J</creatorcontrib><creatorcontrib>SERRACANTA, Jordi</creatorcontrib><creatorcontrib>ARNO, Anna</creatorcontrib><creatorcontrib>HUGUET, Pere</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARRET, Juan P</au><au>GAVALDA, Joan</au><au>COLLADO, Jose M</au><au>SALAMERO, Pere</au><au>MORENO, Carlos</au><au>DEULOFEU, Roser</au><au>MARTINEZ-IBANEZ, Vicenç</au><au>BUENO, Javier</au><au>NUVIALS, Xavier</au><au>PONT, Teresa</au><au>MASNOU, Nuria</au><au>COLOMINA, Maria J</au><au>SERRACANTA, Jordi</au><au>ARNO, Anna</au><au>HUGUET, Pere</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Full Face Transplant: The First Case Report</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>254</volume><issue>2</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue have been transplanted. Herein we report a "full" face transplant including all intact aesthetic and functional units.
On March 27, 2010, we performed a full face transplant, including all the soft tissues and part of the underlaying bony structure, at the University Hospital Vall d'Hebron, Barcelona, Spain. The donor was a 41-year-old male, who died from a massive brain hemorrhage. The recipient was a 30-year-old male with a severe facial deformity caused by a ballistic trauma in 2005. Harvest and subsequent implant took 24 hours. The patient received initial induction (Thymoglobulin 2 mg/kg/iv; Prednisone 1 gm/iv) and maintenance (Prednisone 1 mg/kg/24hours, Tacrolimus 10-15 ng/mL/PO, and Mycophenolate mofetil 2g/daily/PO) immunosuppression and Infection prophylaxis (Valganciclovir and Co-trimoxazole).
There were no intraoperative complications. Postoperative complications included; venous anastomoses thrombosis, acute oro-cutaneous fistula, right parotid sialocele and 2 acute rejection episodes, which were resolved by revision of the anastomosis, profuse irrigation and immunotherapy adjustment, respectively. The patient was discharged from the hospital at 4 months posttransplant with; near-total sensation and partial-motor recovery, no psychological complications and excellent acceptance of his new facial appearance.
The early success described in this case report demonstrates the technical and clinical feasibility of transplanting all the tissues of the with all its aesthetic and functional units intact.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21772126</pmid><doi>10.1097/SLA.0b013e318226a607</doi><tpages>5</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Drug Therapy, Combination Esthetics Facial Injuries - surgery Facial Transplantation - methods Feasibility Studies General aspects Graft Rejection - drug therapy Humans Immunosuppressive Agents - administration & dosage Male Medical sciences Microsurgery - methods Patient Satisfaction Postoperative Care Postoperative Complications - etiology Postoperative Complications - surgery Reoperation Spain Tissue and Organ Harvesting - methods Tissue Donors Transplantation, Homologous Wound Healing - physiology Wounds, Gunshot - surgery |
title | Full Face Transplant: The First Case Report |
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