Principles for designing fluorescent sensors and reporters

Sensors and reporters are among the most exciting tools used in cell biology. Now, they are increasingly used in developmental biology and medicine because they allow us to spy on events in living cells and organisms, including humans, in real time and with high spatial resolution. Herein, we discus...

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Veröffentlicht in:	Nature chemical biology 2011-07, Vol.7 (8), p.480-483
Hauptverfasser:	Lemke, Edward A, Schultz, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1888/2249 631/1647/666 Biochemical Engineering Biochemistry Bioorganic Chemistry Biosensing Techniques - methods Cell Biology Cell Physiological Phenomena Cellular biology Chemistry Chemistry and Materials Science Chemistry/Food Science commentary Fluorescence Humans Indicators and Reagents Sensors
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Beschreibung
Zusammenfassung:	Sensors and reporters are among the most exciting tools used in cell biology. Now, they are increasingly used in developmental biology and medicine because they allow us to spy on events in living cells and organisms, including humans, in real time and with high spatial resolution. Herein, we discuss multiple design options for fluorescent sensors and reporters as well as strategies to improve their properties and increase development.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.620