Osteocalcin Biomimic Recognizes Bone Hydroxyapatite

Osteocalcin Biomimic Recognizes Bone Hydroxyapatite

Twinkle, twinkle little bone! A short peptide derived from a natural bone binding protein, osteocalcin, shows excellent selectivity and affinity to hydroxyapatite, the main component of bone. With a fluorescent label, the intravenously injected peptide revealed detailed bone structures in mice, like...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2011-07, Vol.12 (11), p.1669-1673
Hauptverfasser: Lee, Jae Sam, Tung, Ching-Hsuan
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Bone and Bones - metabolism
Durapatite - chemistry
Durapatite - metabolism
fluorescent probes
Humans
hydroxyapatite
Mice
Mice, Nude
molecular imaging
Molecular Sequence Data
osteocalcin
Osteocalcin - chemistry
Osteocalcin - metabolism
peptidomimetics
Peptidomimetics - chemistry
Peptidomimetics - metabolism
Peptidomimetics - pharmacokinetics
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Beschreibung
Zusammenfassung:Twinkle, twinkle little bone! A short peptide derived from a natural bone binding protein, osteocalcin, shows excellent selectivity and affinity to hydroxyapatite, the main component of bone. With a fluorescent label, the intravenously injected peptide revealed detailed bone structures in mice, like an X‐ray image (see figure).
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201100162