Photoprotective Effects of Methoxycinnamidopropyl Polysilsesquioxane

A new sunscreen ingredient, methoxycinnamidopropyl polysilsesquioxane (MCP‐PSQ), which contains an UV‐absorbing p‐methoxycinnamoyl group, has been developed synthetically and evaluated using in vitro and in vivo approaches. Previous studies revealed that MCP‐PSQ has a raising or boosting effect on t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Photochemistry and photobiology 2011-07, Vol.87 (4), p.920-924
Hauptverfasser: Choi, Dae-Kyoung, Jung, Taek Kyu, Lim, Tae-Yeon, Kim, Tae-Heung, Kim, Young Baek, Lee, Jeung-Hoon, Yoon, Kyung-Sup, Yoon, Tae-Jin
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new sunscreen ingredient, methoxycinnamidopropyl polysilsesquioxane (MCP‐PSQ), which contains an UV‐absorbing p‐methoxycinnamoyl group, has been developed synthetically and evaluated using in vitro and in vivo approaches. Previous studies revealed that MCP‐PSQ has a raising or boosting effect on the sun protection factor (SPF) of other sunscreen agents. In this study, we demonstrated that MCP‐PSQ, an organic/inorganic hybrid compound, has photoprotective effects for human fibroblasts, and for hairless mouse and human skin. MCP‐PSQ increases cell viability and suppresses the expression of p53 protein in fibroblasts after UV exposure. In addition, the numbers of sunburn cells and mast cells are reduced by topical application of MCP‐PSQ on hairless mouse skin after UV irradiation. A 10% MCP‐PSQ cream has higher and similar effects on SPF values for human skin compared to 5% titanium dioxide (TiO2) and 5% ethylhexyl methoxycinnamate (EHMC), respectively. The SPF value obtained using the MCP‐PSQ cream did not drop after UV irradiation of the cream itself. However, higher dose of UV irradiation is required to guarantee the stability or photostability of the formulation. Further, there were no side effects such as erythema, edema, itch or tingling, suggesting that MCP‐PSQ is a good sunscreen agent. The chemical structure of the organic/inorganic hybrid compound, methoxycinnamidopropyl polysilsesquioxane (MCP‐PSQ) and its spherical morphology photographed by the scanning electron microscope. This new sunscreen ingredient has been developed synthetically and evaluated using in vitro and in vivo approaches. We found that MCP‐PSQ compound has good photoprotective effects for human fibroblasts, and for hairless mouse and human skin. Also we demonstrated the high SPF value for human skin. Further, there were no side effects such as erythema, edema, itch or tingling, suggesting that MCP‐PSQ is a good sunscreen agent.
ISSN:0031-8655
1751-1097
DOI:10.1111/j.1751-1097.2011.00940.x