Does Motor Performance Matter in Botulinum Toxin Efficacy for Drooling?

Abstract The aim of this study was to define factors that influence therapy outcome of submandibular botulinum toxin injections for drooling in children with cerebral palsy or mental disability. We postulated that differences in response may be explained by the variation of dysfunctions in the vario...

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Veröffentlicht in:	Pediatric neurology 2011-08, Vol.45 (2), p.95-99
Hauptverfasser:	Erasmus, Corrie E., MD, Scheffer, Arthur R.T., MD, van Hulst, Karen, MSc, van Limbeek, Jacques, MD, PhD, van den Hoogen, Frank J.A., MD, PhD, Rotteveel, Jan J., MD, PhD, Jongerius, Peter H., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Botulinum Toxins, Type A - administration & dosage Child Child, Preschool Female Humans Male Medical sciences Motor Skills Disorders - complications Motor Skills Disorders - drug therapy Muscle Neurology Pediatrics Pharmacology. Drug treatments Predictive Value of Tests Prospective Studies Sialorrhea - drug therapy Sialorrhea - etiology Submandibular Gland - drug effects Submandibular Gland - physiology Treatment Outcome Young Adult
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Zusammenfassung:	Abstract The aim of this study was to define factors that influence therapy outcome of submandibular botulinum toxin injections for drooling in children with cerebral palsy or mental disability. We postulated that differences in response may be explained by the variation of dysfunctions in the various cerebral palsy subtypes. Prospectively collected data were evaluated of 80 spastic and 48 dyskinetic children, of whom 70% had an IQ of
ISSN:	0887-8994 1873-5150
DOI:	10.1016/j.pediatrneurol.2011.02.011