Seizure control: A secondary benefit of chemotherapeutic temozolomide in brain cancer patients

Summary The severity of brain tumor associated seizures often mirror the growth of the underlying tumor, and may be intractable to conventional antiepileptic drugs. We present a patient with intractable seizures in the setting of a low grade glioma who responded dramatically to temozolomide despite...

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Veröffentlicht in:	Epilepsy research 2011-08, Vol.95 (3), p.270-272
Hauptverfasser:	Hu, Alexander, Xu, Zhiqiang, Kim, Ryan Y, Nguyen, Angel, Lee, Jong Woo, Kesari, Santosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiepileptic drugs Antineoplastic Agents, Alkylating - therapeutic use Astrocytoma - complications Biological and medical sciences Brain Neoplasms - complications Brain Neoplasms - drug therapy Brain tumor Chemotherapy Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electroencephalography Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical sciences Nervous system (semeiology, syndromes) Neurology Seizure Seizures - drug therapy Seizures - etiology Temozolomide
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Zusammenfassung:	Summary The severity of brain tumor associated seizures often mirror the growth of the underlying tumor, and may be intractable to conventional antiepileptic drugs. We present a patient with intractable seizures in the setting of a low grade glioma who responded dramatically to temozolomide despite minimal radiographic change in tumor size. Temozolomide is an effective treatment for seizure control in patients with brain tumors.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2011.03.018