HAGIL (Hamburg Vigil Study): a randomized placebo-controlled double-blind study with modafinil for treatment of fatigue in patients with multiple sclerosis

Objective: To reassess the effect of modafinil, a wakefulness-promoting artificial psychostimulant, on fatigue and neuropsychological measures in patients with multiple sclerosis. Methods: Multiple sclerosis (MS) patients with a baseline score of ≥4 on the Fatigue Severity Scale (FSS) and an Expande...

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Veröffentlicht in:	Multiple sclerosis 2011-08, Vol.17 (8), p.1002-1009
Hauptverfasser:	Möller, F, Poettgen, J, Broemel, F, Neuhaus, A, Daumer, M, Heesen, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzhydryl Compounds - therapeutic use Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Double-Blind Method Fatigue - drug therapy Fatigue - etiology Female Humans Male Medical sciences Multiple Sclerosis - complications Multiple Sclerosis - drug therapy Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuroprotective Agents - therapeutic use
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Zusammenfassung:	Objective: To reassess the effect of modafinil, a wakefulness-promoting artificial psychostimulant, on fatigue and neuropsychological measures in patients with multiple sclerosis. Methods: Multiple sclerosis (MS) patients with a baseline score of ≥4 on the Fatigue Severity Scale (FSS) and an Expanded Disability Status Scale score
ISSN:	1352-4585 1477-0970
DOI:	10.1177/1352458511402410