Estimation of Ochratoxin A in human blood of healthy Tunisian population

Human exposure to Ochratoxin A (OTA) has been investigated in many Mediterranean countries, where OTA was found with a higher frequency in foodstuffs and blood samples. The aim of this study was to assess OTA concentrations in human blood serum in Tunisia and to evaluate the impact of several factor...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2010-09, Vol.62 (5), p.539-542
Hauptverfasser:	Karima, Hmaissia-Khlifa, Ridha, Ghali, Zied, Aouni, Chekib, Mazigh, Salem, Machgoul, Abderrazek, Hedhili
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Biological and medical sciences Carcinogens - analysis Chromatography, High Pressure Liquid Female Healthy individuals Human blood Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Ochratoxin A Ochratoxins - blood Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tunisia Young Adult
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Zusammenfassung:	Human exposure to Ochratoxin A (OTA) has been investigated in many Mediterranean countries, where OTA was found with a higher frequency in foodstuffs and blood samples. The aim of this study was to assess OTA concentrations in human blood serum in Tunisia and to evaluate the impact of several factors (age, origin, sex) on these prevalence reference values. One hundred and seven blood serum samples from healthy subjects were analyzed using a solid-phase extraction linked to a high-performance liquid chromatography (HPLC) method. OTA values ranged from 0 to 3.43 ng/mL with a mean value of 0.49±0.67 ng/mL. OTA levels were higher in the Sahal group. Our results reflect OTA concentration previously detected for human blood in Tunisia. Origin, but not age and sex, may affect the OTA reference values.
ISSN:	0940-2993 1618-1433
DOI:	10.1016/j.etp.2009.07.005