Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats
Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results pro...
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| Veröffentlicht in: | Nature genetics 2001-02, Vol.27 (2), p.156-158 |
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| container_title | Nature genetics |
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| creator | Pravenec, Michal Landa, Vladimir Zidek, Vaclav Musilova, Alena Kren, Vladimir Kazdova, Ludmila Aitman, Timothy J. Glazier, Anne M. Ibrahimi, Azeddine Abumrad, Nada A. Qi, Nianning Wang, Jia-Ming St. Lezin, Elizabeth M. Kurtz, Theodore W. |
| description | Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension. |
| doi_str_mv | 10.1038/84777 |
| format | Article |
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Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/84777</identifier><identifier>PMID: 11175782</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animal Genetics and Genomics ; Animals ; Animals, Genetically Modified ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; brief-communication ; Cancer Research ; Care and treatment ; CD36 Antigens - biosynthesis ; CD36 Antigens - genetics ; Cd36 gene ; Cell metabolism, cell oxidation ; Cell physiology ; Diagnosis ; Fatty acids ; Fatty Acids - blood ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic testing ; Genetics ; Glucose Tolerance Test ; Hominids ; Human Genetics ; Hypertension ; Hypertension - genetics ; Identification and classification ; Insulin resistance ; Insulin Resistance - genetics ; Metabolism ; Mitochondrial DNA ; Molecular and cellular biology ; Monkeys & apes ; Multifactorial traits ; Physiological aspects ; Population ; Publishing ; Rats ; Rats, Inbred SHR ; Research centers ; Risk factors</subject><ispartof>Nature genetics, 2001-02, Vol.27 (2), p.156-158</ispartof><rights>Springer Nature America, Inc. 2001</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-a2448b835291bc55ae7cff4ebb26f8447cc4b8cae34e61e0a3d2710b0cebd5d03</citedby><cites>FETCH-LOGICAL-c557t-a2448b835291bc55ae7cff4ebb26f8447cc4b8cae34e61e0a3d2710b0cebd5d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/84777$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/84777$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=912293$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11175782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pravenec, Michal</creatorcontrib><creatorcontrib>Landa, Vladimir</creatorcontrib><creatorcontrib>Zidek, Vaclav</creatorcontrib><creatorcontrib>Musilova, Alena</creatorcontrib><creatorcontrib>Kren, Vladimir</creatorcontrib><creatorcontrib>Kazdova, Ludmila</creatorcontrib><creatorcontrib>Aitman, Timothy J.</creatorcontrib><creatorcontrib>Glazier, Anne M.</creatorcontrib><creatorcontrib>Ibrahimi, Azeddine</creatorcontrib><creatorcontrib>Abumrad, Nada A.</creatorcontrib><creatorcontrib>Qi, Nianning</creatorcontrib><creatorcontrib>Wang, Jia-Ming</creatorcontrib><creatorcontrib>St. Lezin, Elizabeth M.</creatorcontrib><creatorcontrib>Kurtz, Theodore W.</creatorcontrib><title>Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>brief-communication</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>CD36 Antigens - biosynthesis</subject><subject>CD36 Antigens - genetics</subject><subject>Cd36 gene</subject><subject>Cell metabolism, cell oxidation</subject><subject>Cell physiology</subject><subject>Diagnosis</subject><subject>Fatty acids</subject><subject>Fatty Acids - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic testing</subject><subject>Genetics</subject><subject>Glucose Tolerance Test</subject><subject>Hominids</subject><subject>Human Genetics</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Identification and classification</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Metabolism</subject><subject>Mitochondrial DNA</subject><subject>Molecular and cellular biology</subject><subject>Monkeys & apes</subject><subject>Multifactorial traits</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>Publishing</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Research centers</subject><subject>Risk factors</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0t2L1DAQAPAiinee9y9IUVR86JmvJunjsfhxcHCgp68hTSdrjjZdM624_72pu7isiEof0k5-M-mEKYpzSi4o4fq1Fkqpe8UprYWsqKL6fn4nklaCcHlSPEK8I4QKQfTD4oRSqmql2WkBt8lGXEMMrkyAboZy9GUHHtwUvkG56rgs7QB9GJOdAMsQce5DXHDAyUYHOVTiZoz5A8YZ-235ZbuBNEHEpUJOw8fFA297hPP9elZ8evvmdvW-ur55d7W6vK5cXaupskwI3Wpes4a2OWRBOe8FtC2TXguhnBOtdha4AEmBWN4xRUlLHLRd3RF-Vrzc1d2k8esMOJkhoIO-3_2a0UpJQqSQWb74q1REMq4E_SekqqGcNMvZT3-Dd-OcYm7XMMaklE3dZPRsh9a2BxOiH6dk3VLRXFLNBc9OZHXxB5WfDobgxgg-5PhRwqujhGwm-D6t7Yxorj5--H978_nYPt9Zl0bEBN5sUhhs2hpKzDJ25ufYZfdk3_vcDtAd1H7ODn1vLDrb-zx0LuAv11DGGn64a8wbcQ3pcIXH5_0AeLTnmg</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Pravenec, Michal</creator><creator>Landa, Vladimir</creator><creator>Zidek, Vaclav</creator><creator>Musilova, Alena</creator><creator>Kren, Vladimir</creator><creator>Kazdova, Ludmila</creator><creator>Aitman, Timothy J.</creator><creator>Glazier, Anne M.</creator><creator>Ibrahimi, Azeddine</creator><creator>Abumrad, Nada A.</creator><creator>Qi, Nianning</creator><creator>Wang, Jia-Ming</creator><creator>St. Lezin, Elizabeth M.</creator><creator>Kurtz, Theodore W.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20010201</creationdate><title>Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats</title><author>Pravenec, Michal ; Landa, Vladimir ; Zidek, Vaclav ; Musilova, Alena ; Kren, Vladimir ; Kazdova, Ludmila ; Aitman, Timothy J. ; Glazier, Anne M. ; Ibrahimi, Azeddine ; Abumrad, Nada A. ; Qi, Nianning ; Wang, Jia-Ming ; St. Lezin, Elizabeth M. ; Kurtz, Theodore W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-a2448b835291bc55ae7cff4ebb26f8447cc4b8cae34e61e0a3d2710b0cebd5d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>brief-communication</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>CD36 Antigens - biosynthesis</topic><topic>CD36 Antigens - genetics</topic><topic>Cd36 gene</topic><topic>Cell metabolism, cell oxidation</topic><topic>Cell physiology</topic><topic>Diagnosis</topic><topic>Fatty acids</topic><topic>Fatty Acids - blood</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pravenec, Michal</au><au>Landa, Vladimir</au><au>Zidek, Vaclav</au><au>Musilova, Alena</au><au>Kren, Vladimir</au><au>Kazdova, Ludmila</au><au>Aitman, Timothy J.</au><au>Glazier, Anne M.</au><au>Ibrahimi, Azeddine</au><au>Abumrad, Nada A.</au><au>Qi, Nianning</au><au>Wang, Jia-Ming</au><au>St. Lezin, Elizabeth M.</au><au>Kurtz, Theodore W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>27</volume><issue>2</issue><spage>156</spage><epage>158</epage><pages>156-158</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>11175782</pmid><doi>10.1038/84777</doi><tpages>3</tpages></addata></record> |
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| subjects | Agriculture Animal Genetics and Genomics Animals Animals, Genetically Modified Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Care and treatment CD36 Antigens - biosynthesis CD36 Antigens - genetics Cd36 gene Cell metabolism, cell oxidation Cell physiology Diagnosis Fatty acids Fatty Acids - blood Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic testing Genetics Glucose Tolerance Test Hominids Human Genetics Hypertension Hypertension - genetics Identification and classification Insulin resistance Insulin Resistance - genetics Metabolism Mitochondrial DNA Molecular and cellular biology Monkeys & apes Multifactorial traits Physiological aspects Population Publishing Rats Rats, Inbred SHR Research centers Risk factors |
| title | Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats |
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