Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results pro...

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Veröffentlicht in:	Nature genetics 2001-02, Vol.27 (2), p.156-158
Hauptverfasser:	Pravenec, Michal, Landa, Vladimir, Zidek, Vaclav, Musilova, Alena, Kren, Vladimir, Kazdova, Ludmila, Aitman, Timothy J., Glazier, Anne M., Ibrahimi, Azeddine, Abumrad, Nada A., Qi, Nianning, Wang, Jia-Ming, St. Lezin, Elizabeth M., Kurtz, Theodore W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Animals, Genetically Modified Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Care and treatment CD36 Antigens - biosynthesis CD36 Antigens - genetics Cd36 gene Cell metabolism, cell oxidation Cell physiology Diagnosis Fatty acids Fatty Acids - blood Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic testing Genetics Glucose Tolerance Test Hominids Human Genetics Hypertension Hypertension - genetics Identification and classification Insulin resistance Insulin Resistance - genetics Metabolism Mitochondrial DNA Molecular and cellular biology Monkeys & apes Multifactorial traits Physiological aspects Population Publishing Rats Rats, Inbred SHR Research centers Risk factors
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Zusammenfassung:	Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/84777