Sox9 induces testis development in XX transgenic mice

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-det...

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Veröffentlicht in:	Nature genetics 2001-07, Vol.28 (3), p.216-217
Hauptverfasser:	Schedl, Andreas, Vidal, Valerie P.I, Chaboissier, Marie-Christine, de Rooij, Dirk G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial chromosomes Biological and medical sciences Classical genetics, quantitative genetics, hybrids Disorders of Sex Development Female Fundamental and applied biological sciences. Psychology Gene mutations Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Gonads High Mobility Group Proteins - genetics Male Mice Mice, Transgenic Mutation Phenotype Physiological aspects Polymerase chain reaction Publishing Sox9 gene SOX9 Transcription Factor Sry gene Testis Transcription Factors - genetics Transgenic animals Vertebrata X Chromosome - genetics Y chromosomes
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Beschreibung
Zusammenfassung:	Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/90046