Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the aut...

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Veröffentlicht in:	Nature genetics 2007-07, Vol.39 (7), p.830-832
Hauptverfasser:	Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon, Mathew, Christopher G
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Autophagy - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Case-Control Studies Chromosomes Crohn Disease - genetics Crohn's disease Deserts Diagnosis Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Function Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genomics GTP-Binding Proteins - genetics Human Genetics Humans Medical sciences Mice Other diseases. Semiology Physiological aspects Polymorphism, Single Nucleotide Risk factors Sequence Analysis, DNA Single nucleotide polymorphisms Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Zusammenfassung:	A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 × 10 −4 , combined P = 2.1 × 10 −10 ) and for nine other loci, including NKX2-3 , PTPN2 and gene deserts on chromosomes 1q and 5p13.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng2061