Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc

Therapy for infection with HIV-2 remains limited. We report an HIV-2-infected patient in whom genotyping demonstrated PI, NRTI and NNRTI resistance, with a subsequent response to raltegravir- and maraviroc-based therapy. Further studies are required to assess the clinical efficacy of maraviroc in HI...

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Veröffentlicht in:	Antiviral research 2010-05, Vol.86 (2), p.224-226
Hauptverfasser:	Armstrong-James, Darius, Stebbing, Justin, Scourfield, Andrew, Smit, Erasmus, Ferns, Bridget, Pillay, Deenan, Nelson, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cyclohexanes - therapeutic use Drug Resistance, Viral Genotype Genotyping HIV Infections - drug therapy HIV Infections - virology HIV-2 HIV-2 - isolation & purification Human immunodeficiency virus 2 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Maraviroc Medical sciences Outcome Pharmacology. Drug treatments Pyrrolidinones - therapeutic use Raltegravir Raltegravir Potassium RNA, Viral - genetics Treatment Outcome Triazoles - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Therapy for infection with HIV-2 remains limited. We report an HIV-2-infected patient in whom genotyping demonstrated PI, NRTI and NNRTI resistance, with a subsequent response to raltegravir- and maraviroc-based therapy. Further studies are required to assess the clinical efficacy of maraviroc in HIV-2 infection.
ISSN:	0166-3542 1872-9096
DOI:	10.1016/j.antiviral.2010.02.324