Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain

Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain

A mitochondria-trackable fluorophore, CDy2, selectively labels Cys302 in the active site of mitochondrial aldehyde dehydrogenase (ALDH2).

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular bioSystems 2011-08, Vol.7 (8), p.2375-2378
Hauptverfasser: Kim, Yun Kyung, Lee, Jin Kak, Lee, Jun-Seok, Yoon, Chang No, Chang, Young-Tae
Format: Artikel
Sprache:eng
Schlagworte:
Affinity Labels - chemistry
Affinity Labels - metabolism
Aldehyde Dehydrogenase - chemistry
Aldehyde Dehydrogenase - genetics
Aldehyde Dehydrogenase - metabolism
Binding Sites
Cysteine - chemistry
Cysteine - metabolism
Fluorescent Dyes - chemistry
Fluorescent Dyes - metabolism
HEK293 Cells
Heterocyclic Compounds, 3-Ring - chemistry
Heterocyclic Compounds, 3-Ring - metabolism
Humans
Mitochondria - metabolism
Mutagenesis, Site-Directed
Piperidines - chemistry
Piperidines - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A mitochondria-trackable fluorophore, CDy2, selectively labels Cys302 in the active site of mitochondrial aldehyde dehydrogenase (ALDH2).
ISSN:1742-206X
1742-2051
DOI:10.1039/c1mb05137g