Hydrogen-Bond-Directed 2-D Sheet Assemblies of Sulfamide Derivatives: Formation of Giant Vesicles with Patchwork-Like Surface Pattern

Sulfamide derivatives showed high ability to form hydrogen-bond-directed two-dimensional (2-D) sheet assemblies of nanometer thickness. Further, fine-tuning of the side chain structures and preparation conditions allowed for the formation of micrometer-sized giant vesicles of 4b in water by the simple injection method. IR and XRD studies indicated that 4b having tetradecyl and oxyethylene-terminated alkyl side chains formed hydrogen-bond-directed 2-D nanosheet pairs. SEM, AFM, and TEM observation of the dried vesicles revealed that the vesicle membrane was composed of several lamellar-stacked layers of 2-D nanosheets and showed a characteristic patchwork-like pattern on the surface.