Itaconic acid derivatives and diketopiperazine from the marine-derived fungus Aspergillus aculeatus CRI322-03

Three metabolites, pre-aurantiamine ( 1), (−)-9-hydroxyhexylitaconic acid ( 4) and (−)-9-hydroxyhexylitaconic acid-4-methyl ester ( 5) were isolated from the marine-derived fungus, A. aculeatus. [Display omitted] ► Three compounds were isolated from the fungus, Aspergillus aculeatus. ► New metabolites were pre-aurantiamine (1) and litaconic acid derivatives 4 and 5. ► Pre-aurantiamine (1), a diketopiperazine, might be a precursor of aurantiamine. Three metabolites, pre-aurantiamine ( 1), (−)-9-hydroxyhexylitaconic acid ( 4) and (−)-9-hydroxyhexylitaconic acid-4-methyl ester ( 5), together with two known compounds, paraherquamide E ( 6) and secalonic acid D ( 7), were isolated from the marine-derived fungus, Aspergillus aculeatus.